Book Description:
Among many research topics, this book considers phytoestrogens, natural compounds found in plants that possess estrogen-like activity. Despite the growing evidence of the health benefits of phytoestrogens, further investigation is needed to better understand their mechanism of actions, the biological outcomes and possible adverse effects. This book chapter summarizes the most recent developments of lanthanide nanorods in the field of biomedical nanotechnology. The cellular uptake of nanoparticles as a function of several parameters, such as polymeric material and surfactant type are considered.
Camptothecins (CPTs) are regarded as one of the most promising anticancer drugs of the twenty-first century. A further chapter describes SAR, QSAR, and the clinical chemistry of CPT derivatives to understand their chemical–biological interactions and side effects.
This book addresses the biological and pharmacological significances of identification and analysis of effective components of natural medicines and describes methods and procedures for identification and analysis. Potential future prospects in the field are provided.
The porphyrazines are an emerging class of compounds exhibiting tremendous potential for use as anti-tumor therapeutic agents and in imaging applications. This book reviews the initial structure-function studies that have been carried out to date on this little-studied class of compounds. A further study hypothesizes that the differences in the biology of breast cancers observed in women of different races are partially related to differences in the secretory activity of adipocytes in the breast tissue. The possible role of adipokines in breast malignancies of women of various races is reviewed.

Table of Contents:
Preface

Phytoestrogens: Biochemical Aspects and Biological Activities;pp. 1-56
(Rita de Cassia da Silveira e Sa, Reproduction Biology Center, Biology Department, Federal Univ. of Juiz de Fora, Juiz de Fora, MG, Brazil, Luciana Valente Borges, Reproductin Biology Center, Federal Univ. of Juiz de Fora, Juiz de Fora, MG, Brazil)

(Q)SAR and Clinical Chemistry of Camptothecin Analogues;pp. 57-97
(Rajeshwar P. Verma and Corwin Hansch, Dept. of Chemistry, Pomona College, Claremont, California)

Application of Lanthanide (Ln= Eu & Tb) Nanoparticles in Biology and Medicine;pp. 99-141
(Chittaranjan Patra, Priyabrata Mukherjee, Debabrata Mukhopadhyay, Dept. of Biochemistry and Molecular Biology, Dept. of Biomedical Engineering)

Identification and Analysis of Effective Components in Animal Biofluids following Administration of Natural Medicines;pp. 143-175
(Chenggang Huang, Chunhui Ma, Yihong Tang, Shanghai Institute of Material Medica, Shanghai Institutes for Biological Sciences, Shanghai, P.R. China, Yuanyuan Zhang, Dept. of Microbiology and Microbial Engineering, School of Life Sciences, Fudan Univ., Shanghai, P.R. China)

Frontiers of Molecular Technologies in Noninvasive Prenatal Diagnosis;pp. 177-194
(Sherry Sze Yee Ho, Sonia Baig, Sukumar Ponnusamy, Mahesh Choolani, Dept. of Obstetrics & Gynaecology, Yong Loo in School of Medicine, National Univ. of Singapore)

Polymeric Nanoparticles as Carrier Systems: How does the Material and Surface Charge Affect Cellular Uptake?;pp. 195-220
(Anna Musyanovych* , Katharina Landfester, and Volker Mailänder§
Institute of Organic Chemistry III – Macromolecular Chemistry and Organic Materials, University of Ulm, Ulm, Germany, Max Planck Institute for Polymer Research, Ackermannweg, Mainz, Germany
§Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, Department of Transfusion Medicine, University of Ulm, Ulm, Germany §Internal Medicine III, Johann-Gutenberg-University Clinic, Mainz, Germany)

The Role of 1, 25 Dihydroxy-Vitamin D3 in Immunity to Infectious Disease;pp. 221-237
(Michael Eisenhut, Paediatric Dept., Luton & Dunstable Hospital NHS Trust, Luton, UK)

Generation and Analysis of Disease-Specific Mouse Models by Clinical Chemical Screening;pp. 239-259
(Bernhard Aigner, Birgit Rathkolb, Eckhard Wolf, Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis (LAFUGA), Ludwig-Maximilians-Univ., Munich, Germany)

Gene Therapy of Congenital Disease: Applications, Problems and Prospects;pp. 261-280
(Jixin Yang, Jiexiong Feng, Dept. of Pediatric Surgery, Tongji Hospital, Huazhong Univ. of Science and Technology, Wuhan, China)

Porphyrazine Anti-Tumor Agents;pp. 281-300
(*B. J. Vesper,a,b A. G. M. Barrett,c B. M. Hoffman,d J. A. Radosevicha,b
aCenter for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, I
bJesse Brown VAMC, Chicago, IL,
cDepartment of Chemistry, Imperial College of Science, Technology, and Medicine, London, England
dDepartment of Chemistry, Northwestern University, Evanston, IL, USA)

Expert Commentary

Mass Spectrometry in Clinical Chemistry;pp. 301-303
(Simone Konig, Integrated Functional Genomics, Interdisciplinary Center for Clinical Research, Medical Faculty, Univ. of Muenster, Muenster)

Short Communications

Quantitative Proteome-Disease Relationships (QPDRs) in Clinical Chemistry: Prediction of Prostate Cancer with Spectral Moments of PSA/MS Star Networks;pp. 307-317
(Giulio Ferino, Univ. of Bioinformatics and Connectivity Analysis (UBICA), Institute of Industrial Pharmacy and Dept. of Organic Chemistry, Santiago de Compostela, Spain, Dipartimento Farmaco Chimico Tecnologio, Univ. degli Studi di Cagliari, Cagliari, Italy, Gianni Podda, Dipartimento Farmaco Chimico Tecnologio, Univ. degli Studi di Cagliari, Cagliari, Italy, Eugenio Uriarte, Univ. of Bioinformatics and Connectivity Analysis (UBICA), Institute of Industrial Pharmacy and Dept. of Organic Chemistry, Santiago de Compostela, Spain, and Humberto Gonzalez-Dias, Univ. of Bioinformatics and Connectivity Analysis (UBICA), Institute of Industrial Pharmacy and Dept. of Organic Chemistry, Santiago de Compostela, Spain, Dipartimento Farmaco Chimico Tecnologio, Univ. degli Studi di Cagliari, Cagliari, Italy)

"Not So Innocent" - Adipocytes May Explain Racial Differences in Breast Cancer: Implications for Clinical Chemistry;pp. 319-326
(Francis O. Ikpatt, Errol Berman, and Arpad Szallasi, Dept. of Pathology, St Barnabas Medical Center, Livingston, NJ, Dept. of Pathology, Monmouth Medical Center, Long Branch, NJ)

Analytical Method of Allantoin Detection in Human Sera and the Clinical Significance of this Measurement;pp. 327-333
(Haruhiro Muratsubaki, Keiichiro Enomoto, Dept. of Clinical Chemistry, Faculty of Health Sciences, Kyorin Univ., Hachioji, Tokyo, Japan)

Relationship between Serum Creatine Kinase Activity and Serum Aminotransferase Activity in Patients with Extensive Rhabdomyolysis, Myocardial Necrosis;pp. 335-341
(Nadia Habal and Mark Feldman, Dept. of Internal Medicine, Presbyterian Hospital of Dallas, Dallas, TX)

Index