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Telomeres: Function, Shortening and Lengthening
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Editors: Leonardo Mancini
Book Description:
Telomeres are a region of repetitive DNA at the end of chromosomes, which protects the end of the chromosome from destruction. They protect chromosome ends from degradation and thus prevent chromosome end fusion.
This book describes the relevance of telomeres in the human aging process and the telomere defects that play a role in the premature aging process. Dysfunctional telomeres that can promote chromosome instability, leading to DNA amplifications and terminal deletions-, cell cycle arrest and cell death, are also described.
The biology and function of both telomeres and telomerase are described in this book. The possible connection between telomeres, ageing and senescence, as well as the many disorders and chronic diseases where telomere biology seems to be important are addressed, as well as future therapeutic perspectives.
The importance of this enzyme in cancer is reviewed in this book. The data of various kind of cancers are discussed, in addition to the clinical application of telomere and telomerase in human cancer. The role of telomere dysfunction in apoptosis and senescence, as well as its role in newly proposed models that link telomere loss to chromosome missegregation in mitosis, are explained.
Characteristic differences of telomere lengthening during oocyte and spermatozoa growth(during embryo development) is also reviewed as well as the transcriptional activity at the telomeres of Chironomus (Diptera) and its possible role in the lengthening of the telomeres.
Telomere shortening in Diabetes Mellitus is also described, as well as its association with hypertension, diabetes mellitus, insulin resistance, obesity and cardiovascular mortality.
The notion that alterations in the three-dimensional organization of telomeres may cause malignant transformation is also addressed.

Table of Contents:

Chapter 1. Telomere Dynamics and Biology in Human Progeroid Syndromes pp. 1-75
(Terence Davis, Hannah S. E. Tivey and David Kipling, Dept. of Pathology, School of Medicine, Cardiff Univ., UK)

Chapter 2. The Role of Telomere-Telomerase System in Age-Related Fitness Decline, A Tameable Process pp. 77-132
(Giacinto Libertini, Naples, Italy)

Chapter 3. Cytogenetic Evaluation of Telomere Dysfunction: Chromosomal Aberrations Involving Telomeres and Interstitial Telomeric Sequences pp. 133-185
(Alejandro D. Bolzan, Laboratorio de Citogenetica y Mutagenesis, Instituto Multidisciplinario de Biologia Celular, La Plata, Argentina)

Chapter 4. Telomeres - Telomerase Biology and Their Role in Renal and Other Chronic Diseases pp. 187-220
(Kordinas Vasileios, Dept. of Medical Biopathology, Eginition Hospital, Medical School, Univ. of Athens, Tsirpanlis George, Dept. of Nephrology, General Hospital of Athens, Ioannidis Anastasios, Dept. of Medical Biopathology, Eginition Hospital, Medical School, Univ. of Athens, Dept. of Informatics with Applications in Biomedicine, Univ. of Central Greece, Stylianos Chatzipanagiotou, Dept. of Medical Biopathology, Eginition Hospital, Medical School, Univ. of Athens)

Chapter 5. Telomerase and Telomere Dynamics in Cancer: Clinical Application for Cancer Diagnosis pp. 221-251
(Eiso Hiyama, Natural Science Center for Basic Research and Development, Keiko Hiyama, Dept. of Translational Cancer Research, Hiroshima Univ., Hiroshima, Japan)

Chapter 6. Telomeres and Chromosome Segregation pp. 253-273
(Antonella Sgura, Dept. of Biology, Univ. Roma Tre, Rome, Italy, and Daniela Cimini, Virginia Tech, Dept. of Biological Sciences, Blacksburg, VA)

Chapter 7. Telomere-Based Genome-Protective Responses: A Mammalian Improvement on the Bacterial SOS Response? pp. 275-290
(Barbara A. Gilchrest, Mark S. Eller, Dept. of Dermatology, Boston Univ. School of Medicine, Boston, MA)

Chapter 8. Telomere Lengthening from Oocyte to Embryonic Stem Cell pp. 291-314
(Eva Pericuesta, Miguel Angel Ramirez, Raul Fernandez-Gonzalez, Dept. of Animal Production, INIA, Madrid, Spain, et al.)

Chapter 9. Transcriptional Activity at the Telomeres of Chironomus (Diptera). Its Possible Role in the Lengthening of the Telomeres pp. 315-331
(Diez, J.L., Centro de Investigaciones Biologicas, CSIC, Madrid, Spain, Martinez-Guitarte, J.L., Facultad de Ciencias, UNED, Madrid, Spain, Gorab, E., Depto. de Genetica e Biologia Evolutiva, Sao Paulo, Brazil, Morcillo, G., Facultad de Ciencias, UNED, Madrid, Spain)

Chapter 10. Telomerase Activity: Application to Diagnosis of Human Carcinoma pp. 333-345
(Liliana N. Guerra, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina)

Chapter 11. Telomere Shortening in Diabetes Mellitus pp. 347-362
(Nicholas Tentolouris, Athanasia Papazafiropoulou, First Dept. of Propaededutic Medicine, Athens Univ. Medical School, Athens, Greece)

Chapter 12. Do Alterations in the Three-Dimensional Organization of Telomeres Indicate Malignant Transformation? pp. 363-378
(Sandrine Lacoste, Manitoba Institute of Cell Biology, Univ. of Manitoba, Winnipeg, Manitoba, Canada, Hans Knecht, Dept. d'Hematologie, CHUS, Univ. de Sherbrooke, Sherbrooke, Quebec, Canada and Sabine Mai, Manitoba Institute of Cell Biology, Univ. of Manitoba, Winnipeg, Manitoba, Canada)

Expert Commentaries

A: Telomeres: Function, Shortening and Lengthening pp. 379-386
(Barry Flanary, Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, Florida)

B: Telomerase Regulation in Stem Cells - How to Flip the Switch? pp. 387-390
(Rich Allsopp, Institute of Biogenesis Research, Univ. of Hawaii)

Short Communications

A: Telomeres: Function, Shortening and Lengthening "Telomere Maintenance Mechanisms in Bone and Soft Tissue Tumors" pp. 391-401
(Toshihiro Matsuo, Dept. of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima Univ., Hiroshima, Japan, Takashi Sugita, Dept. of Orthopaedic Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan, Shoji Shimose, Dept. of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima Univ., Hiroshima, Japan, et al.)

B: Genetic Polymorphisms of Human Telomerase Reverse Transcriptase pp. 403-413
(Yumiko Matsubara1*, Mitsuru Murata2, and Yasuo Ikeda1
1Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan, 2Department of Laboratory Medicine, School of Medicine, Keio University, Tokyo, Japan)

C: Genetic Inhibition of Telomere Lengthening in Cancer Prevention and Treatment pp. 415-429
(F. Mathias Bollmann, Univ. Hamburg-Eppendorf, Hamburg, Germany)

D: Clinical Implications of Telomerase Activity in Human Brain Tumors pp. 439-446
(Hyoung-Joon Chun, Choong-Hyun Kim, Koang-Hum Bak, Jae-Min Kim, Dept. of Neurosurgery, School of Medicine, Hanyang Univ., Seoul, Korea)


   Binding: Hardcover
   Pub. Date: 2009
   Pages: 478 pp.
   ISBN: 978-1-60692-350-4
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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