Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Medicine » Neurologic Disorders » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Organic and Medicinal Chemistry
$314.10
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Bestsellers
01.Rett Syndrome: Therapeutic Interventions
02.Biomarkers for Early Diagnosis of Alzheimer's Disease
03.Neurobiology of Mental Disorders
04.Craniospinal Hydrodynamics in Neurodegenerative and Neurological Disorders
05.Research Progress in Alzheimer's Disease and Dementia. Volume 1
06.Glia and Inflammation in Neurodegenerative Disease
07.Drug Related Encephalopathies
08.Focus on Epilepsy Research
09.Research Progress in Alzheimer's Disease and Dementia. Volume 2
10.Traumatic Brain Injury Rehabilitation: A Psychotherapeutic Approach to Loss and Grief
Notifications more
NotificationsNotify me of updates to Biomarkers for Early Diagnosis of Alzheimer's Disease
Tell A Friend
 
Tell someone you know about this product.
Biomarkers for Early Diagnosis of Alzheimer's Disease
Retail Price: $110.00
10% Online Discount
You Pay:

$99.00
Editors: Daniela Galimberti and Elio Scarpini (Univ. of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy)
Book Description:
Alzheimer’s disease (AD) is characterized by the deposition into the brain of amyloid peptide, which originates a cascade of inflammatory events leading eventually to neuronal death. These pathological events likely occur several years before the clinical manifestation of the disease, implying that potential therapeutical interventions are currently started too late to give beneficial results. Recently, growing attention has been paid to the Mild Cognitive Impairment (MCI), considered the prodromal phase of AD, as 80% of subjects with MCI have been shown to develop AD within 5 years. Several studies aimed to identify biological markers to differentiate between normal aging and incipient AD have been carried out, including cerebrospinal fluid (CSF) analysis and neuroimaging. In particular, the evaluation of CSF Amyloid beta (1-42) levels, together with tau and phospotau, are of help for recognizing early AD. Besides, a number of additional molecules are altered in CSF. Other early modifications have been observed in peripheral cells, such as fibroblasts and leukocytes, as well as in serum from patients. Biomarkers for AD represent important tools supporting the clinical diagnosis and the choice of potential therapeutic options. Moreover, they would be of great help for the selection of cohorts of homogeneous patients for clinical trials with new disease-modifying compounds.

This book is aimed to give an update about MCI as prodromal Alzheimer’s disease (AD), to discuss the main known pathological mechanisms at the basis of AD and to describe the possible biomarkers to be used for an early diagnosis of the disease.

Table of Contents:
Preface

Chapter 1: Mild Cognitive Impairment;pp. 1-9
(I. Guidi and D. Galimberti, Department of Neurological Sciences, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy)

Chapter 2: ‘Cogmarkers’ for the Diagnosis of Dementia of the Alzheimer’s Type;pp. 11-28
(A. Monti,1,2, B. Poletti,3, S. Zago1,3)
(1.Department of Neurological Sciences, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
2.Current affiliation CIMeC, Centro Interdipartimentale Mente/Cervello, University of Trento Polo, Rovereto, Italy
3.UO di Neurologia e Laboratorio di Neuroscienze, IRCCS Istituto Auxologico Italiano, Centro Dino Ferrari, University of Milan, Italy)

Chapter 3: The Role of Neuroimaging in the Early Diagnosis of Alzheimer’s Disease;pp. 29-66
(V. Garibotto 1, D. Perani1,2)
1.IRCCS San Raffaele Scientific Institute, Milano, Italy
2.Vita-Salute San Raffaele University, Milano, Italy)

Chapter 4: Cerebrospinal Fluid Biomarkers for Alzheimer’s disease;pp. 67-79
(E. Venturelli, C. Villa, E. Scarpini, Department of Neurological Sciences, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy)

Chapter 5: Alzheimer’s Disease Biomarkers: From Concept to Clinical Utility;pp. 81-122
(H. Vanderstichele 1, G. De Meyer 1, F. Shapiro 1, B. Engelborghs 2, L. Shaw 3, J. Trojanowski 3, 1. Department of Diagnostic Development, Innogenetics NV, Gent, Belgium, 2.Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Belgium, 3. Department of Pathology and Laboratory Medicine, Institute on Aging, Alzheimer’s Disease Center, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA)

Chapter 6: The CSF Analysis in Dementia (video included);pp. 123-156
(A. Petzold, Department of Neuroimmunology & Dementia Research Center, Institute of Neurology, University College London, Queen Square, London, UK)

Chapter 7: Inflammation Related Factors: Role in Alzheimer’s Disease and Use as Biomarkers;pp. 157-210
(R. Veerhuis 1,2,3, S.D. Mulder1, N.A. Verwey 1,4, C. Mulder 1, C.E. Hack 1, J.J.M. Hoozemans 3, M.A. Blankenstein 1, P. Eikelenboom 2,5)
(1.Department of Clinical Chemistry and Alzheimer Center, VU University Medical Center, De Boelelaan, HV Amsterdam, The Netherlands; 2.Department of Psychiatry, VU University Medical Center, De Boelelaan , HV Amsterdam, The Netherlands; 3. Department of Pathology, VU University Medical Center, De Boelelaan , HV Amsterdam, The Netherlands; 4.Department of Neurology and Alzheimer Center, VU University Medical Center, De Boelelaan, HV Amsterdam, The Netherlands; 5. Neurology department, Academic Medical Center, Meibergdreef 9, AZ Amsterdam, The Netherlands)

Chapter 8: The Leukocyte Expression of CD36 and other Biomarkers: Risk Indicators of Alzheimer’s Disease;pp. 211-240
(A.E. Rigamonti 1, S.M. Bonomo 1, M. Giunta 1, E.E. Müller 1, M.G. Gagliano 2, S.G. Cella 1; 1. Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases (CEND), University of Milan, Milan, Italy, 2. Department of Immunoematology and Transfusion Medicine, San Carlo Borromeo Hospital, Milan, Italy)

Chapter 9: The Role of Oxidative Stress and Vasoactive Substances in the Pathophysiology of Alzheimer’s Disease;pp. 241-263
(G. Aliev 1,2, C.J. Cobb 1, J.C. Shenk 1,2, P.I. Moreira 3, K. Fischbach,1,2, G. Perry 4,5; 1.Department of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA; 2. Department of Electron Microscopy Research Center, College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA; 3. Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal
4.Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA; 5College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA)

Chapter 10: Role of Apolipoprotein E in Neurodegeneration;pp. 265-279
(C. Lovati, University of Milan, Ospedale L. Sacco, Milan, Italy)

Index

   Binding: Hardcover
   Pub. Date: 2008, 4th quarter
   Pages: 307 pp.
   ISBN: 978-1-60456-991-9
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
Customers who bought this product also purchased
Cell Apoptotic Signalling Pathways
Cell Apoptotic Signalling Pathways
Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
Stem Cell Transplantation, Tissue Engineering and Cancer Applications
Stem Cell Transplantation, Tissue Engineering and Cancer Applications
Bacterial Endocarditis: Etiology, Pathogenesis and Interventions
Bacterial Endocarditis: Etiology, Pathogenesis and Interventions
Hematopoietic Stem Cell Transplantation Research Advances
Hematopoietic Stem Cell Transplantation Research Advances
T-Cell Vaccination
T-Cell Vaccination
Special Focus Titles
01.Peter Singer’s Ethics: A Critical Appraisal
02.Sexism: Past, Present and Future Perspectives
03.Body and Politics: Elite Disability Sport in China
04.Childhood and Adolescence: Tribute to Emanuel Chigier, 1928-2017
05.Renal Replacement Therapy: Controversies and Future Trends
06.Food-Drug Interactions: Pharmacokinetics, Prevention and Potential Side Effects
07.Terrorism and Violence in Islamic History and Theological Responses to the Arguments of Terrorists
08.International Event Management: Bridging the Gap between Theory and Practice
09.The Sino-Indian Border War and the Foreign Policies of China and India (1950-1965)
10.Tsunamis: Detection, Risk Assessment and Crisis Management
11.Sediment Watch: Monitoring, Ecological Risk Assessment and Environmental Management
12.Self-Regulated Learners: Strategies, Performance, and Individual Differences

Nova Science Publishers
© Copyright 2004 - 2018

Biomarkers for Early Diagnosis of Alzheimer's Disease