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01.Gene Silencing: New Research
02.New Research on DNA Damage
03.Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
04.MicroRNA let-7: Role in Human Diseases and Drug Discovery
05.Myelin Basic Protein
06.New Research on Genomic Instability
07.Developmental Gene Expression Regulation
08.Lecture Notes on Computational Mutation
09.Fragile Sites: New Discoveries and Changing Perspectives
10.Progress in Stem Cell Applications
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Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
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Editors: Annapia Verri (IRCCS- Neurological Inst. C. Mondino Foundation, Pavia, Italy)
Book Description:
This book provides professionals with the latest and most reliable information about genetic disorders and emphasizes the advantage of a lifespan multidisciplinary approach. The maturation of the brain, the environmental experiences and the mastery of developmental challenges and task are considered in order to understand how persons with genetic disorders and intellectual disability progress throughout their life-span from infancy to old age.

The book utilizes a developmental perspective and reviews different genetics disorders associated with intellectual disabilities (Down Syndrome, Turner syndrome, Nance Horan Syndrome, 10p deletion), with focus mainly at the developmental history. It also provides useful indications for support to children and adults with developmental disabilities regarding education and other best practices like family supports and cognitive enrichment programs. A Brief introduction to intelligence provides an overview of topical intelligence research and theory, in terms that can be integrated with the results and theory of neuropsychology.

Case studies are proposed in each chapter to highlight specific diagnostic and treatment issues and to discuss the facilitation of transitions throughout the lifespan from infancy to maturity and old age. Focusing developmental features for addressing the etiological diagnosis and comparing brain development and mind/brain interactions among neurogenetic syndromes is the promising approach to understand neurodevelopment underlined throughout the book.

Table of Contents:
Introduction: Intelligence: An overview;pp. 1-8
(T. C. Bates)

1.Diagnostic evaluation of the child affected with Intellectual Disability: a clinical genetic perspective;pp. 9-31
(A. Cereda, A. Passarini, M. Cerutti, D. Milani, F. Menni, A. Selicorni)
2.Down Syndrome (DS): Brain and beyond the Brain. The biological profile of DS;pp. 33-63
(A. Verri, L. Nespoli, D. Franciotta, G. R. Burgio)

3.Life span development in Turner Syndrome (TS);pp. 65-83
(A. Verri, V.Destefani, A. Cremante, D. Larizza

4.Life span development in Klinefelter Syndrome;pp. 85-92
(L. Tarani)

5.Life span development in XYY;pp. 93-105
(M. Vernice)

6.Neurobiological Advances in the Fragile X Family of Disorders and Targeted Treatment;pp. 107-122
(R. Hagerman, M. Ono)

7.Life span development in Nance-Horan Syndrome (NHS);pp. 123-134
(S. Russo, A. Verri, V. Destefani, F. Cogliati, MT. Dotti)

8.Idiopathic hypoparathyroidism and Chromosome 10p Deletion;pp. 135-145
(A. Verri, P. Maraschio)

9.Life span development in Interstitial Deletion Chromosome 21;pp. 147-155
(A. Verri, A. Cremante,B. Caterina, F. Clerici,M. G. Egitto,E.Alfonsi

10.Cognitive Enrichment Issue;pp. 157-171
V. Destefani)

Rehabilitation issues;pp. 173-194
(M. Bartolo, M. Dulio, G. Sandrini)

12.Narrative Based Medicine in Genetic Syndromes with Intellectual Disability;pp. 195-212
(C. Ruggerini, F. Vezzosi, A. Solmi, S. Manzotti)

Index pp.213-236

   Binding: Hardcover
   Pub. Date: 2008, 4th quarter
   Pages: pp.236
   ISBN: 978-1-60456-839-4
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects