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Progress in Cell Cycle Control Research
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Editors: K. L. Chen
Book Description:
A cell cycle is an ordered and highly controlled set of events that leads to cell growth and proliferation. Cell cycle progression is driven by changes in the substrate specificity and subcellular localization of cyclin-dependent kinases (Cdks), which in turn are modulated by a collection of cyclins, Cdk-activating and Cdk-inhibiting kinases, and Cdk inhibitors (CDKIs). Regulation of the cell cycle is critical for the normal development of multicellular organisms and dysregulation of cell cycle could lead to cancer, a disease where normal cell growth and behavior are lost. Cell cycle regulation is tightly controlled by both synthesis and degradation of short-lived proteins, such as cyclins and CDKIs, and degradation of these proteins is mainly mediated by the ubiquitin-dependent proteasome pathway.This new book presents the latest research in the field from around the globe.

Table of Contents:
Preface

Sizing Up Answers to a Long-Standing Riddle; pp.1-38
(Arkadi Manukyan, Noelle Zavala, Brandt L. Schneider, Department of Cell Biology and Biochemistry, Texas Tech University Health Science Center, Lubbock, TX)

New Directions for CDKs and HDACs Inhibition in Cancer Therapy; pp.39-74
(Graziano Lolli and Stefania Di Marco, Instituto di Ricerche di Biologia Molecolare "P. Angeletti", Via Pontina Km, Pomezia, Rome, Italy)

^ Genetic and Epigenetic Alterations of Cell Cycle Control Genes in Hematological Malignancies and Their Restoration Using Molecular Targeted Therapy; pp.75-114
( Takashi Kumagai, Department of Hematology, Ohme Municipal General Hospital, Tokyo, Japan)

Cell Cycle Control by Proteasome Inhibition: Implications in Cancer Therapies; pp.115-146
(Vesna Milacic, Q. Ping Dou, The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan, USA)

Cell-Cycle Regulation by Protein Kinase C and Mitogen-Activated Protein Kinase Signaling in Breast Cancer Cells; pp.147-164
(Teruhiko Fujii, Goro Yokoyama, National Hospital Organization Kyushu Medical Center, Breast Care Center, Clinical Research Institute, Fukuoka, Japan, Department of Surgery, Kurume University, Kurume, Japan, Uhi Toh, Department of Surgery, Kurume University, Kurume, Japan, Hideaki Yamana, Multidisciplinary Treatment Center, Kurume University, Kurume, Japan, Kazuo Shirouzu, Department of Surgery, Kurume Univertsity, Kurume, Japan)

Fhit and Cancer Initiating Cells; pp.165-174
(Hideshi Ishii, Center for Molecular Medicine, Jichi Medical University, Tochigi, National Institute of Radiological Science, Chiba, Japan, Saito Toshiyuki, National Institute of Radiological Science, Chiba, Japan)

Anti-Tumorigenic Mechanisms Targeting Control of Cell Cycle Beyond the Conserved G1/S and Gs/M Checkpoints - Insights Learned from Studies of Reversine, a Substituted Purine with Regenerative Potential, in Human Prostate Cancer PC-3 Cells; pp.175-196
(Tze-Chen Hsieh, Zhirong Wang, Joseph M. Wu, New York Medical College, Department of Biochemistry and Molecular Biology, Valhalla, NY, USA)

Cell Cycle Control Proteins in Human Breast Cancer; pp.197-220
(Ignacio Garcia-Tuñón, Mar Royuela, Department of Cell Biology and Genetics, University of Alcalá)

Catalytic Therapy of Cancer Review; pp.221-238
(Nadejda Razanova, University of California, Santa Cruz, Diane Heck, Rutgers University, NJ)

Bladder Cancer and Retinoids: TGF-α and VEGF as End-Point Biomarkers
Retinoid Treatment of Bladder Cancer; pp.239-254
(Tarek H. El-Metwally, Department Medical Biochemistry, Faculty of Medicine, Assiut University)

^ Skin Cancers and the Cell Cycle pp.255-274
(S. Ch’ng1,2, S.T. Tan1, P. Davis2, H. Brasch3, M. Sullivan4, 1Wellington Regional Plastic, Maxillofacial & Burns Unit, Hutt Hospital, Wellington, New Zealand
2Department of Medicine, Wellington School of Medicine & Health Sciences, Wellington, New Zealand
3Department of Pathology, Hutt Hospital, Wellington, New Zealand
4Children’s Cancer Research Group, Christchurch School of Medicine & Health Sciences, Christchurch, New Zealand)
(Maricela Rodriguez-Cruz, Raúl Sánchez, Laboratorio de Biología Molecular, Unidad de Investigación Médica en Nutrición, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social(IMSS), México, D.F., México)

Retinoblastoma Protein Family: Primary Roles in Cell Cycle Regulation pp. 275-294
(Maricela Rodriguez-Cruz and Raul Sanchez)

The Roles of Mammalian Mitogen-Activated Protein Kinase-Activating Protein Kinases (MAPKAPKs) in Cell Cycle Control; pp. 295-320
(Sergiy Kostenko, Alexey Shiryaev, Nancy Gerits, Ugo Moens, University of Tromsø, Faculty of Medicine, Institute of Medical Biology, Department of Microbiology and Virology, Tromsø, Norway)

Index

   Binding: Hardcover
   Pub. Date: 2008, 4th Quarter
   ISBN: 978-1-60456-797-7
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Progress in Cell Cycle Control Research