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Medicine Research Summaries. Volume 20
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Bacterial Endocarditis: Etiology, Pathogenesis and Interventions
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Authors: Claudia L. Dominguez and Alba M. Ramos 
Book Description:
Infective endocarditis (IE) is a microbial infection of the endocardium. In subacute IE, the previously-damaged surface of cardiac valve becomes the starting point for the deposition of platelets and the formation of a platelet-fibrin clot. IE develops after bacteria enters the bloodstream and colonize the clot. Platelets and fibrin mount up over the bacteria, increasing the size of the vegetation. As additional layers of fibrin are added, leukocytes are incapable to break through the vegetation. Treatment with antibiotics can also be problematic because the bacteria within the vegetation often become less metabolically active, and many antibiotics require active bacterial growth to be effective. The overall incidence of infective endocarditis is 1.7 to 4.0 per 100,000 population and in adults older than 50 years, it exceeds 15 per 100,000 population. Almost 50-60% of cases of acute IE do not necessitate an underlying heart condition to be present. The microorganisms most accountable for the development of acute IE (e.g. S. aureus) are exceedingly virulent and able to colonize normal heart valves. The incidence of acute IE has been progressively rising and now surpasses the number of subacute IE cases. Presenting symptoms and clinical signs include fever, malaise, weight loss, splenomegaly, cardiac murmur, petechiae, Roth’s spots, Janeway lesions and Osler nodes. This book provides leading-edge research on this field from around the world.

Table of Contents:
Preface

Infective Endocarditis pp. 1-41
(Ioannis Starakis, Department of Internal Medicine, Patras University Hospital, Rion, Patras, Greece)

Infective Endocarditis in Hemodialysis Patients pp. 43-56
(Jigishu Dhabuwalla, Desikan Kamalakannan, Louis D Saravolatz, Department of Internal Medicine, St. John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA)

Infective Endocarditis: Role of Dental Infections pp. 57-68
(J.H. Meurman, Institute of Dentistry, University of Helsinki, Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland, R. Rautemaa, Institute of Dentistry, University of Helsinki, Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, A. Bascones, School of Dentistry, Complustense University of Madrid, Spain)

Infective Endocarditis in Patients 70 Years Old or Older: Differential Features and Prognosis (Endocarditis in Elderly Patients) pp. 69-75
(Martín Ruiz, Manuel Anguita, Juan C. Castillo, Mónica Delgado, Francisco Torres, José Suárez de Lezo, Cardiology Service, Hospital Universitario Reina Sofia, Cordoba, Spain, Cardiology Service, Hospital Costa del Sol, Marbella, Spain)

Periannular Complications Associated with Infective Endocarditis: Diagnosis and Treatment pp. 77-87
(Maura Nataloni, Outpatient Cardiology Department, Fabriano Hospital, Ancona, Italy, Martina Pergolini, Cardiology Department, Jesi Hospital, Ancona, Italy, Roberto Mocchegiani, Lancisi Heart Hospital, Ospedali Riuniti, Ancona Italy)

Pathophysiology and the Prevention of Bacterial Endocarditis (BE) pp. 89-98
(Warren G. Guntheroth, University of Washington School of Medicine, UW Medical Center, Seattle, WA)

Q Fever Endocarditis: Clinical Course and Prognosis pp. 99-108
(Juan C. Castillo, Manuel P Anguita, Monica Delgado, Cardiology Department, Hospital Reina Sofia, Cordoba, Spain)

Multi Valvular Involvement pp. 109-126
(Davide Agnelli and Suleiman Al-Kayyali, Coronary Care Unit, Department of Cardiology, "Sacra Famiglia" Hospital, Italy)

Index

   Binding: Hardcover
   Pub. Date: 2008, 4th Quarter
   Pages: 140 pp.
   ISBN: 978-1-60456-761-8
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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