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Myelin Basic Protein
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Editors: Joan M. Boggs (Hospital for Sick Children, Toronto, Ontario, Canada))
Book Description:
The compact myelin sheath formed around nerve axons speeds up nerve conduction and also nurtures the axon. Destruction of this sheath in demyelinating diseases such as multiple sclerosis (MS) results in nerve conduction failure and neurodegeneration. Myelin basic protein (MBP) is the second most abundant protein of central nervous system (CNS) myelin (after the proteolipid protein), representing about 30 % of the total myelin protein and about 10 % of myelin by weight. It is also present in peripheral nervous system (PNS) myelin but as a lower percentage of the total protein. This book addresses the structure, different isoforms, post-translational modifications, immunogenicity, and novel functions of MBP and its possible involvement in MS. MBP is a natively unfolded protein, is conformationally adaptable to different environments, and probably has additional roles in the myelinating cells and in myelin besides its well-established role in adhesion of the cytosolic surfaces of myelin in the CNS.

Table of Contents:
Preface:

Chapter 1. The Properties and Functions of the Golli Myelin Basic Proteins
(Anthony T. Campagnoni and Celia W. Campagnoni, Semel Inst. for Neuroscience and Human Behavior, Univ. of California at Los Angeles Geffen Medical School, Los Angeles, CA)

Chapter 2. Posttranslational Modifications of Myelin Basic Proteins
(Robert Zand, Biophysics –LSA, Univ. of Michigan, Ann Arbor MI)

Chapter 3. Deimination of MBP by PAD enzymes, and Their Role in
Multiple Sclerosis
(Fabrizio G. Mastronardi and Mario A. Moscarello, The Hosp. for Sick Children, Toronto, Ontario, Canada)

Chapter 4. MBP-Mediated Immunopathogenesis in Multiple Sclerosis and EAE
(Qingyong Ji and Joan Goverman, Dept. of Immunology, Univ. of Washington, Seattle, WA)

Chapter 5. A Structural Perspective of Peptides from Myelin Basic Protein
(Maria Katsara, Burnet Institute (Austin Campus), Immunology and Vaccine Laboratory, Studley Road, Heidelberg, Australia,
Department of Chemistry, Section of Organic Chemistry, Biochemistry, and Natural Products, University of Patras, Greece, Theodore Tselios, John Matsoukas, Department of Chemistry, Section of Organic Chemistry, Biochemistry, and Natural Products, University of Patras, Patras, Greece, et al.)

Chapter 6. Interactions of the 18.5 kDa Myelin Basic Protein (MBP) with Lipid Bilayers – Studies by Electron Paramagnetic Resonance (EPR) Spectroscopy and Implications for Generation of Autoimmunity in Multiple Sclerosis
(Joan M. Boggs, Department of Molecular Structure and Function, Research Institute, Hospital for Sick Children, Ontario, Canada, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Ian R. Bates, Department of Molecular and Cellular Biology, and Biophysics Interdepartmental Group, University of Guelph, Guelph, Ontario, Canada, McGill Univ., Montreal, Canada, Abdiwahab A. Musse, Department of Molecular and Cellular Biology, and Biophysics Interdepartmental Group, University of Guelph, Guelph, Ontario, Canada, et al.)

Chapter 7. Insights on the Interaction of MBP with Microtubules
(Mauricio R. Galiano, Cecilia Lopez Sambrooks and Marta E. Hallak;
Centro de Investigaciones en Química Biológica de Córdoba, CIQUIBIC, (UNC-CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina)

Chapter 8. Myelin Basic Protein Interactions with Actin and Tubulin in vitro – Binding, Assembly, and Regulation
(Joan M. Boggs, Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada, Dept. of Laboratory Medicine and Pathobiology, Univ. of Toronto, Canada)

Chapter 9. Molecular Modelling of the Interaction of Myelin Basic Protein (MBP) Peptides With Signalling Proteins and Effects Of Post-Translational Modifications
(Eugenia Polverini, Dept. of Physics, Univ. of Parma, Parma, Italy)

Chapter 10. Structure and Dynamics of the Myelin Basic Protein (MBP) Family by Solution and Solid-State NMR
(George Harauz and Vladimir Ladizhansky, Univ. of Guelph, Ontario, Canada)

Index

   Series:
      Intrinsically Disordered Proteins- Vladimir N. Uversky (Indiana University of Medicine, USA), Series Editor
   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 978-1-60456-699-4
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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