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01.Gene Silencing: New Research
02.New Research on DNA Damage
03.Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
04.MicroRNA let-7: Role in Human Diseases and Drug Discovery
05.Myelin Basic Protein
06.New Research on Genomic Instability
07.Developmental Gene Expression Regulation
08.Lecture Notes on Computational Mutation
09.Fragile Sites: New Discoveries and Changing Perspectives
10.Progress in Stem Cell Applications
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Oligonucleotide Array Sequence Analysis
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Editors: Martina K. Moretti and Lorenzo J. Rizzo
Book Description:
Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases. The length of a synthesized base is usually denoted by 'mer' (from 'Greek' meros "part"). For example, a fragment of 25 bases would be called a 25-mer. Oligonucleotides are often used as probes for detecting complementary DNA or RNA because they bind readily to their complements. Examples of procedures that use oligonucleotides are DNA microarrays, Southern blots, fluorescent in situ hybridization (FISH), and the synthesis of artificial genes. This book brings together leading research in the field from around the globe.

Table of Contents:

Expert Commentaties

Visible Haplotype-TagSNP Typing Array Device for Human Radiation Sensitivity-Associated Genes
(Yuichi Michikawa, Tomo Suga, Atsuko Ishikawa, RadGenomics Project, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Japan, et al.) (pp. 3-14)

Specificity of Oligonucleotide Microarray Hybridization: Effectors and Their Effects
(Hinanit Koltai, Department of Ornamental Horticulture, ARO Volcani Center, Israel, Carmiya Bar-Or, Department of Neurobiology, Weizmann Institute of Science, Israel)(pp. 15-24)

Research and Review Studies

Chapter 1. Selecting A Proper Platform for Microarray Experiment
(Sergey V. Anisimov,V.A. Almazov Federal Center for Heart, Blood and Endocrinology, Saint-Petersburg, Russia, Cureline, Inc., San Francisco, CA) (pp. 27-36)

Chapter 2. The Clinical Relevance of Gene Expression Profiles in Peripheral Blood Mononuclear Cells
(Christopher H. Woelk, Department of Pathology, University of California San Diego, USA, Michael E. Burczynski, Biomarker Laboratory, Wyeth Research, USA) (pp. 37-82)

Chapter 3. Clustering Time-Series Gene Expression Data
(Luis Rueda, Department of Computer Science and Center for Biotechnology, University of Concepcion, Chile, Ataul Bari, School of Computer Science, University of Windsor)(pp. 83-121)

Chapter 4. Recent Advances in Microbial Discovery Using Metagenomics, DNA Microarray, Biosensors, Molecular Subtyping, and Phage Recombinant Probes
(Sufian F. Al-Khaldi, Division of Microbiology, Office of Regulatory Sciences, Magdi M. Mossoba, Betsy Jean Yakes, Division of Analytical Chemistry, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, et al.)(pp. 123-147)

Chapter 5. Statistical Analysis of Tiling-path Microarrays
(Xiangfeng Wang, Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT) (pp. 149-174)

Chapter 6. Application of Microarray in Rat Model of Alcoholic and Non-Alcoholic Liver Disease
(Meena R. Sharma, School of Medicine, University of Pennsylvania, Philadelphia, Mahesh C. Sharmas, Department of Surgery, Drexel College of Medicine, Drexel University, Philadelphia, Amin A. Nanji, Dalhousie University School of Medicine, Canada)(pp. 175-207)

Chapter 7. Biological Interpretation in Oligonucleotide Array Sequence Analysis Based on Molecular Networks
(Hiromi Sato, Life Science Research Department, Institute of Medicinal Molecular Design, Japan)(pp. 209-243)

Chapter 8. Generalized Analysis of Variance (ANOVA) Models for Oligonucleotide Microarray Data Analysis
(Hua Li, Stowers Instiute for Medical Research, Kansas City, MO, Dongxiao Zhu, Dept. of Computer Science, Univ. of New Orleans, New Orleans, LA, Research Institute for Children, New Orleans, LA) (pp. 245-264)

Chapter 9. On Line Tools for Presentation and Analysis of Plant Microarray Data
(David Honys, Nikoleta Dup¾áková, Laboratory of Pollen Biology, Institute of Experimental Botany ASCR, Department of Plant Physiology, Faculty of Science, Charles University, Czech Republic, David Reòák, Laboratory of Pollen Biology, Institute of Experimental Botany ASCR, Department of Plant Physiology, Faculty of Science, Charles University, Czech Republic, Department of Plant Physiology and Anatomy, Faculty of Science, University of South Bohemia, Czech Republic)(pp. 265-295)

Chapter 10. Methods, Strategies and Facts for Improving the Analysis of Genetic Variations Using DNA Arrays
(Rangel-López Angélica, Unidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, México, Méndez-Tenorio Alfonso, Maldonado-Rodríguez Rogelio, Laboratorio de Biotecnología y Bioinformática Genómica, Escuela Nacional de Ciencias Biológicas, México, et al.)(pp. 297-321)

Chapter 11. Improving Detection of Differentially Expressed Genes in Microarrays
Using More Efficient Statistics, the Local Optimal Fudge Factor and a Two-Stage FDR Correction
(Shunpu Zhang, Department of Statistics, University of Nebraska Lincoln, NE)(pp. 323-345)

Chapter 12. Basic Approaches to Gene/Exon Level Data Analysis: 3'IVT and Exon 1.0 ST Microarray Platforms
(Roberta Bosotti, Vanessa Marchesi, Department of Biotechnology, Genomics Lab, Nerviano Medical Sciences, Italy, Raffaele Calogero, Department of Clinical and Biological Sciences, University of Torino, Italy)(pp. 347-366)

Chapter 13. Simultaneous Qualitative and Quantitative Identification of Multiple Targets by Polymerase Chain Reaction on Microarray
(Natalia V Zakharova, State Research Institute of Genetics, Moscow, Alexei L. Drobyshev, Dmitry A Khodakov, Engelhardt Institute of Molecular Biology, Moscow, Russian Federation, et al.)(pp. 367-386)

Chapter 14. Use of Arrays with Non-Model Organisms: A UK Perspective
(Michael J. Allen, Plymouth Marine Laboratory, Plymouth, UK, Andrew R. Cossins, Neil Hall, NERC Molecular Genetics Facility, School of Biological Sciences, Univ. of Liverpool, Liverpool, UK)(pp. 387-402)

Chapter 15. Positional Weight Matrix as a Sequence Motif Detector
(Youlian Pan, Sieu Phan, Institute for Information Technology, National Research Council Canada)(pp. 403-422)

Chapter 16. Quality Control Methods for Oligonucleotide Microarrays
(Manuel Nieto-Díaz, Wolfgang Pita-Thomas, Manuel Nieto-Sampedro, Unidad de Neurología Experimental, Hospital Nacional de Parapléjicos (SESCAM), Spain, Instituto Cajal de Neurobiología (CSIC), Spain)(pp. 423-442)

Chapter 17. Applications of Qiagen QIAplex Technology in Clinical Multiplex Assays
(John Brunstein, Chief Scientific Officer, Centre for Translational and Applied Genomics, PHSA Labs, Clinical Laboratory Scientist, Children's and Women's Health Centre of BC, PHSA Labs, Vancouver BC, Clinical Assistant Professor, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver BC) (pp. 443-456)

Chapter 18. Oncology Applications of Microarray Technology Detecting Small Genomes Variability
(Rossana Scavelli, Sergio Abrignani, Marco Crimi, Functional Genomics Unit, National Institute of Molecular Genetics (INGM), Italy)(pp. 457-467

Chapter 19. Oligonucleotide Arrays in Forensic DNA Testing (Jason Shepard, University at Albany SUNY, NY)(pp. 469-490)


   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 978-1-60456-542-3
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
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PR At Prepress
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Oligonucleotide Array Sequence Analysis