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01.Gene Silencing: New Research
02.New Research on DNA Damage
03.Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
04.MicroRNA let-7: Role in Human Diseases and Drug Discovery
05.Myelin Basic Protein
06.New Research on Genomic Instability
07.Developmental Gene Expression Regulation
08.Lecture Notes on Computational Mutation
09.Fragile Sites: New Discoveries and Changing Perspectives
10.Progress in Stem Cell Applications
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RNA Interference Research Progress
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Editors: Roger T. Lyland and Irving B. Browning
Book Description:
RNA interference (RNAi) is a mechanism that inhibits gene expression by causing the degradation of specific RNA molecules or hindering the transcription of specific genes. RNAi targets include RNA from viruses and transposons (probably as a form of innate immune response), and also plays a role in regulating development and genome maintenance. Small interfering RNA strands (siRNA) are key to the RNAi process, and have complementary nucleotide sequences to the targeted RNA strand. Specific RNAi pathway proteins are guided by the siRNA to the targeted messenger RNA (mRNA), where they "cleave" the target, breaking it down into smaller portions that can no longer be translated into protein. A type of RNA transcribed from the genome itself, microRNA (miRNA), works in the same way. This new book presents the latest research in the field from around the globe.

Table of Contents:

Short Communication

Evaluation of Published Rational siRNA Design Algorithms Using Firefly Luciferase Gene as a Reporter
(Yuki Naito, Kaoru Saigo, Kumiko Ui-Tei, Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan)pp. 3-11

Research and Review Studies

1. Applications of RNAi in C. Elegans Research
(Julián Cerón, Nanomedicine Program, CIBBIM, Valle Hebron Hospital Research Institute, Barcelona, Spain, Juan Cabello, Centro de Investigación del Cáncer, Salamanca, Spain, José Manuel Monje, Centro Andaluz de Biología del Desarrollo (CABD-CSIC), Departamento de Biología Molecular e Ingeniería Bioquímica, Universidad Pablo de Olavide, Sevilla, Spain) pp. 15-50

2. Vector-based RNAi in Chicken Embryos in vivo
(Fangping Dai, Beate Brand-Saberi - Institute of Anatomy and Cell Biology, Freiburg University, Freiburg, Germany) pp. 51-73

3. Optimal siRNA Sequence Design for RNA Interference
(Shigeru Takasaki, RIKEN Genomic Sciences Center (GSC), Kanagawa, Japan) pp. 75-102

4. SiRNA Silencing Efficacy Prediction
(Shibin Qiu, Pathwork Diagnostics Inc, Sunnyvale, CA) pp. 103-134

5. RNA Interference: From Functional Genomics to Validation of Drug Targets in Helminths
(Sara Lustigman, Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, USA, Louise Ford, Filariasis Research Group, Liverpool School of Tropical Medicine, UK, Michael J. Crawford, Divergence Inc., Missouri, USA) pp. 135-162

6. Regulation of Metabolism, Aging and Lifespan by MicroRNAs
(Junlong Zhang, Clinical Sciences Research Institute, Walsgrave Hospital Campus, Coventry) pp. 163-187

7. Gene Silencing by Double-Stranded RNA in Apis Mellifera: A Useful Reverse Genetics Approach for Studying Complex Biological Phenomena
(Tahira Farooqui, Department of Entomology, The Ohio State University, USA) pp. 189-210

8. Induction of RNA Interference by Episomal Transcriptionally Silent Homologous DNA
(Mohammad Bahman Bahramian, Impedagen, LLC, USA) pp. 211-229

9. RNA Silencing and DNA Methylation in Plants
(A.K.M. Nazmul Haque, Masamichi Nishiguchi, Faculty of Agriculture, Ehime Univ., Matsuyama, Japan) pp. 231-257

10. RNA Silencing and Plant Defence Against Viral and Non-Viral Pathogens
(Sameer Tiwari, Commonwealth Scientific and Industrial Research Organization, Division of Plant Industry, Canberra, Australia, Ren Zhang, School of Biological Sciences, Univ. of Wollongong, Australia)pp. 259-279

11. Polymers for siRNA Delivery in Vivo
(Achim Aigner, Department of Pharmacology and Toxicology Philipps-University Marburg, Germany) pp. 281-299


   Binding: Hardcover
   Pub. Date: 2008, 3rd Quarter
   ISBN: 978-1-60456-446-4
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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RNA Interference Research Progress