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Natural Killer T-Cells: Roles, Interactions, and Interventions
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Editors: Nathan V. Fournier
Book Description:
Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer (NK) cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self- and foreign lipids and glycolipids. Upon activation, NK T cells are able to produce large quantities of interferon-gamma, IL-4, and granulocyte-macrophage colony-stimulating factor, as well as multiple other cytokines and chemokines (such as IL-2 and TNF-alpha). NKT cells seem to be essential for several aspects of immunity because their dysfunction or deficiency has been shown to lead to the development of autoimmune diseases (such as diabetes or atherosclerosis) and cancers. NKT cells have recently been implicated in the disease progression of human asthma. The clinical potential of NKT cells lies in the rapid release of cytokines (such as IL-2, IFN-gamma, TNF-alpha, and IL-4) that promote or suppress different immune responses.

Table of Contents:

Chapter 1 - NKT Cell-associated Diseases and Related-treatments;
pp. 1-49
(Tan Jinquan, Li Li, Wang Li, Department of Immunology, Wuhan University School of Basic Medical Sciences, China)

Chapter 2 - Lifestyle and Natural Killer Activity; pp. 51-80
(Kanehisa Morimoto, Osaka University Graduate School of Medicine, Japan, Qing Li, Nippon Medical School, Japan)

Chapter 3 - Organophosphorus Compounds Inhibit Natural Killer Cell Activity; pp. 81-102
(Qing Li, Department of Hygiene and Public Health, Nippon Medical School, Japan)

Chapter 4 - NKT Cells: Dual Role in Tumor Immunosurveillance and Implications in Cancer Immunotherapy; pp. 103-128
(Sergiy S. Olishevsky, Alexandra L. Sevko, Volodymyr O. Shlyakhovenko, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine)

Chapter 5 - Natural killer T Cells in Peripheral Tolerance;
pp. 129-141
(Michael Nowak, Beth Israel Deaconess Medical Center Harvard Medical School, Boston)

Chapter 6 - Possible Clinical Use of NK Cells for the Control of Hematologic Malignancies; pp. 143-153
(Giovanni F. Torelli, Roberta Maggio, Maria G. Mascolo, Department of Cellular Biotechnologies and Hematology, University “La Sapienza”, Italy)

Chapter 7 - Natural Killer Cell Receptor NKG2A/HLA-E Interaction Dependent Differential Thymopoiesis of Hematopoietic Progenitor Cells Influences the Outcome of HIV Infection; pp. 155-171
(Edmond J. Yunis, Viviana Romero and Prasad Koka)

Chapter 8 - Optimizing the Use of BETA Glycolipids as NKT Cell Ligands; pp. 173-187
(Tomer Adar, Ami Ben Ya'acov, Gadi Lalazar, Hebrew University, Hadassah Medical Center, Israel)


   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 978-1-60456-287-3
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Natural Killer T-Cells: Roles, Interactions, and Interventions