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Alpha Lipoic Acid: New Perspectives and Clinical Use in Obstetrics and Gynecology
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Editors: Vittorio Unfer (A.G.UN.CO Obstetrics and Gynecology Center, Rome, Italy)
Book Description:
Alpha Lipoic Acid: New Perspectives and Clinical Use in Obstetrics and Gynecology focuses on the rationale of Alpha-lipoic Acid (ALA) use in the field of maternal-fetal medicine and its clinical applications.

So far, the use of ALA is promising in several conditions which involve inflammation, oxidation, and tissue damage in their pathophysiology. Indeed, several studies provide a reliable amount of data related to the therapeutic use of ALA in different disorders such as cancer, neurodegenerative diseases, diabetes, tissue regeneration, ischemia–reperfusion injury, and aging.

According to the multiple actions of ALA and its safe profile, the book provides valuable updates regarding the positive role of ALA supplementation from implantation to parturition, and includes research and information from newer published studies in this field.
The rationale of ALA use in obstetrics, the current preclinical and clinical evidences on the administration of ALA to maintain the physiological state of pregnancy and treat pathological conditions such as threatened miscarriage, and preterm delivery represent the core of this composition.

In addition, to contain the core science of ALA in pregnancy, this book is designed to serve both as a valuable clinical reference for the obstetricians and as a starting point for the development of new experimental and clinical studies on the use of ALA in pregnancy. (Nova Biomedical)

Book Reviews

“Although the mode of action and clinical applications of ALA have been extensively studied, this book is still unique. It fills a gap by focusing on the effects and use of this compound in normal or pathological gestation. The eight chapters of the book cover several aspects of reproduction, including the effects of ALA on wound healing in uterine injury, its beneficial effects on the length of gestation, as well as on fetal membrane weakening. The use of different routes of administration, safety considerations, even the possible use of alpha lipoic acid in assisted reproduction are discussed. I believe this book will make a useful and inspiring reading for both practicing clinicians and for scientists working in the field.” - Julia Szekeres-Bartho M.D., Ph.D., D.Sc. Dept of Medical Biology, Medical School, Pecs University, Hungary

"Accumulating evidence suggests that alpha-lipoic acid (ALA) protects against tissue damage by exerting beneficial effects on inflammation and oxidation. This compendium comprehensively and adeptly summarizes the relevant research and our current understanding of the biologic actions of ALA. More importantly, each chapter also addresses a possible therapeutic use of ALA in various gynecologic and reproductive disorders. As a result, the compendium will serve as a useful resource and guide for anyone interested in the clinical utility or research opportunities of ALA in reproductive medicine." - John E. Nestler, M.D., MACP William Branch Porter Professor of Medicine Chair, Department of Internal Medicine Virginia Commonwealth University, Richmond, Virginia, USA

"The book titled “ Alpha Lipoic Acid: new perspectives and clinical use in obstetrics and gynaecology” presents a delightful review of latest information for those who want to enjoy the opinions of doctors on this specific topic. This book can provide a reference for the development of new experimental and clinical studies on the use of ALA in pregnancy. I congratulate editor ‘Vittorio Unfer’ to bring out the latest information on role of Alpha Lipoic Acid in Maternal-Fetal medicine in the form of this book." - Vaishali Agte B. Sc., M.Sc., Ph.D., Retired Emeritus Scientist and Director, Innova Foods, Pune, India

"This book provides interesting information on the possible role of ALA supplementation in IVF. Several immunological and inflammatory actions together with the powerful protective antioxidant activities of ALA may be related to an improvement of IVF outcomes and to a reduction of early pregnancy loss." - Tony Chiu Ph.D., M.Sc., Mteach, MLT. Hong Kong People's Republic of China

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Table of Contents:

Chapter 1. Alpha Lipoic Acid in Obstetrics: Rationale for Use in Clinical Practice (pp. 1-54)
(Marco Tilotta, Sara De Grazia and Vittorio Unfer)

Chapter 2. The Effects of Lipoic Acid on Wound Healing in a Uterine Injury Rat Model: Clinical Perspectives in Obstetric Surgery (pp. 55-72)
(Asli Goker and Naci Kemal Kuscu)

Chapter 3. The Use of Lipoic Acid in Supporting Pregnancy Physiology and Pregnancy Length: Preclinical Evaluation (pp. 73-88)
(Serap Cilaker Micili and Bekir Ugur Ergür)

Chapter 4. Lipoic Acid Effects upon Human Fetal Membrane Weakening (pp. 89-134)
(Anudeepa Sharma, Robert M. Moore, John J. Moore and Deepak Kumar)

Chapter 5. Clinical Use of Oral Lipoic Acid in Pregnancy (pp. 135-162)
(Giusi Porcaro)

Chapter 6. Clinical Use of Vaginal Lipoic Acid in Pregnancy (pp. 163-174)
(Lucrezia Pignatti and Fabio Facchinetti)

Chapter 7. Safe Use of Lipoic Acid in Pregnancy (pp. 175-202)
(Antonio Simone Laganà)

Chapter 8. The Potential Role of Lipoic Acid in Assisted Reproductive Technologies (pp. 203-222)
(Kostantinos Ravanos and Nikos Prapas)

About the Editor (pp. 223-224)

Index (pp. 225)

Total Pages: 236

      Therapeutic Approaches in Common Obstetrics and Gynecological Disorders
   Binding: Hardcover
   Pub. Date: 2018 - May
   ISBN: 978-1-53613-592-3
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Alpha Lipoic Acid: New Perspectives and Clinical Use in Obstetrics and Gynecology