Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Ebooks » Biomedical Sciences » Biology » Cell Biology » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Atomic Force Microscopy: Principles, Developments and Applications
$82.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Bestsellers
01.Cell Transplantation: New Research
02.Eosinophils: Structure, Biological Properties and Role in Disease
03.Regulatory T Cells
04.Adult Stem Cell Survival
05.Cytoskeleton: Cell Movement, Cytokinesis and Organelles Organization
06.Desmoplastic Small Round Cell Tumor
07.DNA Damage Repair, Repair Mechanisms and Aging
08.DNA Repair: New Research
09.Erythropoietin: Human Production, Potential Uses and Adverse Effects
10.Exosomes: Biogenesis, Therapeutic Applications and Emerging Research
Notifications more
NotificationsNotify me of updates to mRNA: Molecular Biology, Processing and Function
Tell A Friend
 
Tell someone you know about this product.
mRNA: Molecular Biology, Processing and Function $82.00
Editors: Irma Fernandez and Lynn Jackson
Book Description:
In this collection, the authors review the currently available data on interactions of ribosomal components with canonical mRNAs and with hepatitis C virus (HCV)-like IRESes during translation and on conformational rearrangements in the ribosomes accompanying these interactions. This review considers data obtained by biochemical approaches, primarily by site-directed cross-linking with the application of mRNA and IRES analogues bearing reactive groups in definite locations, and models for translational complexes of higher eukaryotic ribosomes derived from cryo-electron microscopy. Afterwards, the authors discuss how the addition of the poly(A) tail of 30-100 adenosines to the 3´-end of mRNA has been shown to be important for the stability, nuclear export, export of mRNA to the cytoplasm and translation of a transcript. The molecular mechanism responsible for the definition of a poly(A) site includes several recognition, cleavage and polyadenylation factors that identify the poly(A) signal, usually AAUAAA hexamer and similar variants, located 10-35 nucleotides upstream of the cleavage site. The process known as SUMO (small ubiquitin-related modifier) conjugation to a lysine residue in the target protein or sumoylation is a rapid, reversible post-transcriptional modification is also examined. Similar to ubiquitin, SUMO isoforms are conjugated to their targets by a isopeptide bond between their C-terminal glycine and the ɛ-NH2 group of the target lysine residue. Next, the authors discuss splicing of pre-mRNAs coding for proteins. Since the discovery of frequent spliceosomal gene mutations which occur in about 65% of patients with myelodysplastic syndrome (MDS), we know that splicing factor gene mutations are the most frequent mutations found in MDS patients. Predominantly, four splicing factor genes (SF3B1, SRSF2, U2AF1, ZRSR2) are mutated in MDS and related malignancies. In closing, the authors present their findings that splicing is not only necessary for obtaining correct open reading frames, but also leads to deposition of the exon junction complex core. Essentially, all pre-mRNAs are cleaved and polyadenylated with exception of histone mRNAs. (Nova Biomedical)

Table of Contents:
Preface

Chapter 1. The Interaction of mRNA with Ribosomes in the Course of Translation in Higher Eukaryotes
(Dmitri Graifer and Galina Karpova, Laboratory of Ribosome Structure and Functions, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia, and others)

Chapter 2. Formation of the 3´-Ends of Eukaryotic Messenger RNAs – Polyadenylation and Alternative Polyadenylation
(Ota Fuchs, Institute of Hematology and Blood Transfusion, Prague, Czech Republic)

Chapter 3. Regulatory Roles of Sumoylation in Messenger RNA Processing and Metabolism
(Ota Fuchs, Institute of Hematology and Blood Transfusion, Prague, Czech Republic)

Chapter 4. Frequent Alterations in Messenger RNA Splicing in Myelodysplastic Syndromes
(Ota Fuchs, Institute of Hematology and Blood Transfusion, Prague, Czech Republic)

Chapter 5. The Close Coupling of a Nucleocytoplasmic Messenger Ribonucleoproten Particle Export and the Biogenesis of Messenger Ribonucleoprotein Particle
(Ota Fuchs, Institute of Hematology and Blood Transfusion, Prague, Czech Republic)

Index

   Series:
      Cell Biology Research Progress
   Binding: ebook
   Pub. Date: 2018 - 1st quarter
   ISBN: 978-1-53613-169-7
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
Available Options:
Version:
Special Focus Titles
01.Essays on the Philosophical Nexus between Religion and Politics. Volume 2
02.Glaciology for Glacial Geologists
03.Tropical Fruits: From Cultivation to Consumption and Health Benefits, Fruits from the Amazon
04.The Copper Garden: New Zealand Novels
05.Informed Parents, Healthy Kids: Information You Need to Know to Find the Right Mental Health Practitioner
06.An Echo of Silence: A Comprehensive Research Study on Early Child Marriage (ECM) in Iran
07.Panic Disorder: Assessment, Management and Research Insights
08.Multiple Sclerosis in Children and Adolescents
09.Parkinson’s Disease: Awareness among Young Adults
10.Cancer and Exercise
11.Psychobiological, Clinical, and Educational Aspects of Giftedness
12.Why 40%-80% of Chronic Pain Patients Are Misdiagnosed and How to Correct That

Nova Science Publishers
© Copyright 2004 - 2018

mRNA: Molecular Biology, Processing and Function