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Osteoclastogenesis: Research Advances and Clinical Challenges
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Editors: Masayoshi Yamaguchi, PhD (Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, US)
Book Description:
Bone is a dynamic tissue that undergoes continual adaptations during a vertebrate’s lifespan to attain and preserve skeletal size, shape, and structural integrity, and plays a pivotal role in regulating mineral homeostasis in a living body. Bone homeostasis, which maintains bone mass, is artfully regulated through osteoclasts, osteoblasts and osteocytes in bone tissues. This mechanism is regulated through many hormones, cytokines and immune systems in the bone marrow microenvironment. Aging leads to a reduction in bone mass, which is reduced by a suppression of osteoblastic bone formation and an enhancement in osteoclastic bone resorption. A decrease in bone mass leads to osteoporosis and bone fracture. Osteoporosis is widely recognized as a major public health problem. Moreover, bone loss is shown to stimulate in various pathophysiological states, including inflammation, obesity, diabetes, and cancer cell bone metastasis. Disease associated with bone loss is strongly related to osteoclastic bone resorption. This book focuses recent research topics implicated in osteoclastogenesis and clinical challenges to prevent and treat bone loss. (Nova Biomedical)



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Table of Contents:
Preface

Chapter 1. Osteoclast Fusion: An Important Biological Behavior for Osteoclast Function (pp. 1-12)
(Ce Dou and Shiwu Dong)

Chapter 2. Osteoclastogenesis: The Role of Regucalcin as a Novel Stimulator like Cytokine (pp. 13-38)
(Masayoshi Yamaguchi)

Chapter 3. Osteoclastogenesis and Drug Discovery (pp. 39-62)
(Yan-Qiu Liu)

Chapter 4. Some Plant-Derived Natural Products Inhibited Osteoclast Formation and Function (pp. 63-80)
(Yueqi Chen and Shiwu Dong)

Chapter 5. A New Approach to Osteoporosis Treatment: Suppression of Osteoclastic Bone Resorption with Nutritional and Botanical Factors (pp. 81-182)
(Masayoshi Yamaguchi)

About the Editor (pp. 183-184)

Index (pp. 185)

Total Pages: 191

   Series:
      Human Anatomy and Physiology
   Binding: Softcover
   Pub. Date: 2017 - 4th Quarter
   ISBN: 978-1-53612-629-7
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Osteoclastogenesis: Research Advances and Clinical Challenges