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01.Rett Syndrome: Therapeutic Interventions
02.Biomarkers for Early Diagnosis of Alzheimer's Disease
03.Neurobiology of Mental Disorders
04.Craniospinal Hydrodynamics in Neurodegenerative and Neurological Disorders
05.Research Progress in Alzheimer's Disease and Dementia. Volume 1
06.Glia and Inflammation in Neurodegenerative Disease
07.Drug Related Encephalopathies
08.Focus on Epilepsy Research
09.Research Progress in Alzheimer's Disease and Dementia. Volume 2
10.Traumatic Brain Injury Rehabilitation: A Psychotherapeutic Approach to Loss and Grief
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Research Progress in Alzheimer's Disease and Dementia. Volume 3
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Editors: Maio-Kun Sun (Blanchette Rockefeller Neurosciences Inst.)
Book Description:
Alzheimer’s disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterized pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the aging population, unless more effective treatments are developed. Since the publication of the second book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists worldwide. This third book volume contains 15 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics include molecular genetics of AD, gene expression abnormalities in AD progression, presenilins, taupathy in AD, single neuron gene expression abnormalities in AD, intracellular A-induced neurodegeneration, roles of lipoprotein receptors in AD onset and progression, cholesterol and tau hyperphosphorylation, AD diagnostics and therapeutic strategies, in vivo visualization of amyloid-like structures, cathepsin B, antiamyloidogenesis and neuroprotection, environmental enrichment, Fragile X mental retardation gene and dementia, category learning in Parkinson’s disease, cerebrovascular disease and dementia, and dementia and hypertension. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in AD and dementia.

Table of Contents:

Chapter I - Molecular Genetics of Alzheimer’s Disease; pp. 1-23
(Odity Mukherjee; Petra Nowotny; Alison Goate and D.Phil, Washington Univ. School of Medicine, St. Louis, Mo)

Chapter II - Gene Expression Abnormalities Mark the Progression of Alzheimer's Disease; pp. 25-58
(Stephen D. Ginsberg; Shaoli Che; Scott E. Counts and Elliott J. Mufson, Physiology & Neuroscience, N.Y. Univ. School of Medicine, Orangeburg, NY and Dept. of Neurological Sciences, Rush Univ. Medical Center, Chicago, IL)

Chapter III - Presenilins; pp. 59-77
(Gopal Thinakaran, Dept. of Neurobiology and Neurology, Univ. of Chicago, Chicago, IL)

Chapter IV - Taupathy in Alzheimer’s Disease; pp. 79-93
(Roland Brandt and Monika Hundelt Dept. of Neurobiology, Univ. of Osnabrück, Germany)

Chapter V - Intraneuronal -Amyloid-Induced Neurodegeneration and Alzheimer’s Dementia; pp. 95-734
(Sarah L. Cole and Robert Vassar, Northwestern Univ. The Feinberg School of Medicine, Chicago, IL)

Chapter VI - Lipoprotein Receptors in Alzheimer's Disease;
pp. 135-176
(Olav M. Andersen and Thomas E. Willnow, Dept. for Molecular and Cardiovascular Research, Robert-Roessle-Strasse 10, Berlin, Germany)

Chapter VII - Cholesterol and Tau Hyperphosphorylation in Alzheimer’s Disease; pp. 177-191
(Thomas G. Ohm and Volker Meske, Inst. of Integrative Neuroanatomy, Dept. of Clinical Cell- and Neurobiology, Berlin, Germany)

Chapter VIII - Development in Diagnostic and Therapeutic Strategies for Alzheimer’s Disease; pp. 193-250
(Akila Shanmugam, Bernhard Monien and Gal Bitan
Dept. of Neurology, David Geffen School of Medicine, Brain Research Inst. and Molecular Biology Inst., Univ. of Calif., Los Angeles, CA)

Chapter IX - In Vivo Visualization of Amyloid Like Structures with Pet Molecular Imaging Probes; pp. 251-273
(Vladimir Kepe; Sung-Cheng Huang; Nagichettiar Satyamurthy; Gary W. Small and Jorge R. Barrio, David Geffen School of Medicine at UCLA, G.W.S., Univ. of Calif. at Los Angeles, Los Angeles, CA)

Chapter X - Cathepsin-B, Antiamyloidogenesis, and Neuroprotection; pp. 275-302
(Li-Gan, Gladstone Inst. of Neurological Disease, Univ. of Calif. San Francisco, Ca.

Chapter XI - Environmental Enrichment: From Mouse AD Model to AD Therapy; pp. 303-328
(Orly Lazarov and John Larson, Univ. of Illinois at Chicago, Chicago, IL)

Chapter XII - Fragile X Mental Retardation Gene and Dementia;
pp. 329-338
(Maija Castrén1 and Seppo Kaakkola)

Chapter XIII - Category Learning in Parkinson's Disease; pp. 339-365 (J. Vincent Filoteo)

Chapter XIV - Cerebrovascular Disease and Dementia; pp. 367-380
(Ola A. Selnes, Johns Hopkins Univ. School of Medicine, Baltimore, MD)

Chapter XV - Dementia and Hypertension; pp. 381-413
(Jan A. Staessen; Tom Richart; Lutgarde Thijs and Willem H. Birkenhäger, Campus Gasthuisberg, Leuven, Belguim)


      Research Progress in Alzheimer's Disease and Dementia
   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 1-60021-960-8
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
Special Focus Titles
01.Peter Singer’s Ethics: A Critical Appraisal
02.Sexism: Past, Present and Future Perspectives
03.Body and Politics: Elite Disability Sport in China
04.Childhood and Adolescence: Tribute to Emanuel Chigier, 1928-2017
05.Renal Replacement Therapy: Controversies and Future Trends
06.Food-Drug Interactions: Pharmacokinetics, Prevention and Potential Side Effects
07.Terrorism and Violence in Islamic History and Theological Responses to the Arguments of Terrorists
08.International Event Management: Bridging the Gap between Theory and Practice
09.The Sino-Indian Border War and the Foreign Policies of China and India (1950-1965)
10.Tsunamis: Detection, Risk Assessment and Crisis Management
11.Sediment Watch: Monitoring, Ecological Risk Assessment and Environmental Management
12.Self-Regulated Learners: Strategies, Performance, and Individual Differences

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Research Progress in Alzheimer's Disease and Dementia. Volume 3