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Oxidative Stress: Clinical and Biomedical Implications
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Editors: Bashir M. Matata (Cardiothoracic Centre, Liverpool NHS Trust, Liverpool, UK), Maqsood M. Elahi (Cardiothoracic Centre Liverpool NHS Trust, Liverpool, UK)
Book Description:
There is an emerging concept that nitric oxide (NO), its derivatives and reactive oxygen intermediates (ROS) are the major determinants of the involvement of oxidant stress that contributes to the control of physiological cell signaling processes, blood flow regulation and pathological hypoxia. There is recent published evidence for additional functions of these oxygen metabolites in cardiac gene expression; functions that include the modulation of the cytokine response of lymphocytes and the regulation of immune cell apoptosis as well as immuno-deviating effects. In vitro and in vivo experimental models investigating the biological nature of ROS have shown that there is a concentration dependent effect of NO and that differences in cell sensitivity to NO may have an impact upon the degree of immune or inflammatory state. Disturbances in NO bio-availability leads to loss of cardioprotective actions within biological systems and in some cases may even increase oxidative stress and disease progression. Hence, considerable interest in identifying the mechanisms involved in their generation and implications have spurted in the hope that inhibition strategies can be developed either bio-materially or pharmacologically.
This book brings together the emerging biological concepts of oxidative stress and its connotation in the pathogenesis of various inflammatory processes in biological systems.

Table of Contents:

Chapter I - Ethnic Diversity and Oxidative Stress in Health and Disease; pp. 1-22
(Kamlesh Asotra, PhD., Tobacco-Related Disease Research Program, Univ. of California Office of President, Oakland, CA, M. Phil, Virender K. Rehan, Dept. of Pediatrics, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor-UCLA, David Geffen School of Medicine at UCLA, Torrance, CA)

Chapter II - Mechanisms of ROS Formation; pp. 23-38
(Bashir M Matata, The Cardiothoracic Centre, Liverpool NHS Trust, Liverpool, United Kingdom, Maqsood M Elahi, The Wessex Cardiothoracic Centre, Southampton, United Kingdom)

Chapter III - The Emerging Role of Reactive Oxidant Species in Biomaterials Biocompatibility; pp. 39-57
(Bashir Matata, The Cardiothoracic Centre, Liverpool NHS Trust, Liverpool, United Kingdom, Maqsood M Elahi, The Wessex Cardiothoracic Centre, Southampton, United Kingdom)

Chapter IV - Steady-State Titration with H2O2: Regulation of NF-kB Activation and of Plasma Membrane Permeability by H2O2; pp. 59-67
(Fernando Antunes, Grupo de Bioquímica dos Oxidantes e Antioxidantes, Centro de Química e Bioquímica and Dept. de Química e Bioquímica da Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal, Instituto de Investigação Científica Bento da Rocha Cabral, Cç. Bento da Rocha Cabral, Lisboa, Portugal; Virginia de Oliveira-Marques; Luisa Cyrne and H. Susana Marinho)

Chapter V - Cytoprotection Afforded by ROS after Ischemia-Reperfusion; pp. 69-83
(Dipak Das, Cardiovascular Research Center, Univ. of Connecticut School of Medicine, Farmington, CT and Manika Das)

Chapter VI - Pyruvate: A Physiologic Energy Substrate and Antioxidant for Cardiopulmonary Bypass; pp. 85-102
(Devin C. Flaherty, Robert T. Mallet, Albert H. Olivencia-Yurvati, Dept. of Surgery and Integrative Physiology, Univ. of North Texas Health Science Center, Fort Worth, Texas)

Chapter VII - Redox Regulation of Cell Signaling; pp. 103-132
(Magdalena Circu, Tak Yee Aw, Dept. of Molecular & Cellular Physiology, Louisiana State Univ. Health Sciences Center, Shreveport, Louisiana, USA)

Chapter VIII - Regulation of Oxidative Stress: Dysregulation or Bad Setpoint? Interactions with Basal Nitric Oxide; pp. 133-144
(David R. Whitlock, Nitroceutic LLC, Watertown, MA)

Chapter IX - The Biological Significance of the NO-dependent Mitochondrial Biogenesis; pp. 145-155
(Sestina Falcone, Emilio Clementi, E. Medea Scientific Institute, Italy, Dept. of Preclinical Sciences, Univ. of Milan, Milan, Italy)

Chapter X - S-Nitrosothiols and Disease Mechanisms; pp. 157-170
(Emma L. Taylor, Paul G. Winyard, Inflammation and Musculoskeletal Diseases Research Group, Institute of Biomedical and Clinical Science, Peninsula Medical School, St Luke’s Campus, Exeter, Devon)

Chapter XI - Flavonoids, Endothelial Function, and Cardiovascular Disease; pp. 171-182
(Machha Ajay, Lakehead Univ., Ontario, Canada, Dept. of Pharmacology, Faculty of Medicine, Univ. of Malaya, Kuala Lumpur, Malaysia, Mohd Rais Mustafa, Dept. of Pharmacology, Faculty of Medicine, Univ. of Malaya, Kuala Lumpur, Malaysia)

Chapter XII - NO Regulatory Networks in Bacteria Focusing on Pathogenic Bacteria; pp. 183-201
(Jorge Membrillo Hernández, David S. Zamorano-Sánchez, Gerardo Croda-Garcia, Laboratorio de Microbiología y Genética Molecular, Dept. de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas. Univ. Nacional Autónoma de México, Ciudad Univ., Mexico City, Mexico and Elizabeth Hernandez-Urzua)

Chapter XIII - Endogenous Regulation of Nitric Oxide Synthase Activity and Free Radical Generation; pp. 203-226
(Scott P. Forbes, Yong Xia, Arturo J. Cardounel, From the Davis Heart and Lung Research Institute, Dept. of Pharmacology and Internal Medicine, The Ohio State Univ. College of Medicine, Columbus, OH)

Chapter XIV - NO Dependent and NO Independent Signaling in Cellular Processes; pp. 227-243
(Emil Martin, Ka Bian, Ferid Murad, Brown Foundation Institute of Molecular Medicine, Univ. of Houston Health Science Center)

Chapter XV - The Role of Nitric Oxide in Cardiovascular Diseases; pp. 245-258
(Khalid Naseem, Centre for Atherothrombosis Research, Medical Biosciences, Univ. of Bradford, Richmond Road, Bradford)

Chapter XVI - The Interplay between Airways Inflammation and Reactive Oxygen/Nitrogen Species in Pulmonary Diseases; pp. 259-276
(Serpil Erzurum, Weiling Xu, Serpil C. Erzurum, Dept. of Pathobiology
Pulmonary, Allergy and Critical Care Medicine Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio)

Chapter XVII - Peroxynitrite and Nitrosative Stress in Heart Failure- Role of MMPS, ADP-Ribose and PARP; pp. 277-290
(Pál Pacher, Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institutes of Health, Bethesda MD, Csaba Szabó, Dept. of Surgery, UMD NJ-New Jersey Medical School, Newark, New Jersey)

Chapter XVIII - Reactive Oxidant Species and Emerging Therapies in Clinical Medicine; pp. 291-306
(Farzaneh Daghigh, Dept. of Biochemistry and Molecular Biology, Philadelphia College of Osteopathic Medicine, Philadelphia, PA)


   Binding: Hardcover
   Pub. Date: 2007
   Pages: 7 x 10 330pp.
   ISBN: 1-60021-888-1
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Oxidative Stress: Clinical and Biomedical Implications