Human Clinical Studies Involving Sulforaphane/Glucoraphanin (pp. 239-250)
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Authors: (Bernhard H.J. Juurlink, Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada)
Abstract: Sulforaphane, the metabolite of glucoraphanin, activates the Nrf2 signalling system.
Activation of the Nrf2 signalling system has been shown to positively affect a variety of
disturbances in homeostasis, including disturbances in redox, in intermediary metabolism
and mitochondrial function as well as disturbances in lipid metabolism. Such
disturbances are present in many human diseases suggesting sulforaphane may have
therapeutic effects. A number of studies of the effects of sulforaphane and/or
glucoraphanin have been carried out in humans. This is a review of such studies to date.
Studies reviewed include human pharmacological studies; effects on Helicobacter pylori
infections; responses to allergens; effect on neurological disorders such as autism
spectrum disorder and schizophrenia; effect on the cardiovascular disorders; and effect on
prostate cancer.
