Human Clinical Studies Involving Sulforaphane/Glucoraphanin (pp. 239-250)

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Human Clinical Studies Involving Sulforaphane/Glucoraphanin (pp. 239-250)

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Authors: (Bernhard H.J. Juurlink, Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada)
Abstract: Sulforaphane, the metabolite of glucoraphanin, activates the Nrf2 signalling system. Activation of the Nrf2 signalling system has been shown to positively affect a variety of disturbances in homeostasis, including disturbances in redox, in intermediary metabolism and mitochondrial function as well as disturbances in lipid metabolism. Such disturbances are present in many human diseases suggesting sulforaphane may have therapeutic effects. A number of studies of the effects of sulforaphane and/or glucoraphanin have been carried out in humans. This is a review of such studies to date. Studies reviewed include human pharmacological studies; effects on Helicobacter pylori infections; responses to allergens; effect on neurological disorders such as autism spectrum disorder and schizophrenia; effect on the cardiovascular disorders; and effect on prostate cancer.

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Human Clinical Studies Involving Sulforaphane/Glucoraphanin (pp. 239-250)