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Medicine Research Summaries (with Biographical Sketches). Volume 15
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Beneficial Effects of Broccoli Sprouts and Its Bioactive Compound Sulforaphane in Management of Type 2 Diabetes (pp. 225-238) $100.00
Authors:  (Zahra Bahadoran and Parvin Mirmiran, Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, and others)
Abstract:
Young broccoli sprouts are rich sources of many bioactive compounds, especially
sulforaphane (SFN). Studies have shown that SFN has the potential to activate the
antioxidant response signaling pathway, thereby inducing phase 2 enzymes. This will
attenuate oxidative stress as well as inflammation. SFN, by activating the antioxidant
response, also regulates lipid metabolism and glucose homeostasis. Anti-hypertensive,
anti-cancer, cardio-protective, hypo-cholesterolemic capacity and antibactericidal
properties against Helicobacter Pylori have also been reported for SFN. Clinical studies
with high-SFN broccoli sprouts have shown increased total antioxidant capacity of
plasma and a decrease in the following: the oxidative stress index, lipid peroxidation,
serum triglycerides, oxidized-LDL/LDL-C ratio, serum insulin, insulin resistance, and
serum high sensitive C reactive protein. Thus SFN has the potential to prevent diabetic
vascular complications. Potential therapeutic efficacy of SFN and probably other
bioactive components present in young broccoli sprouts make it as an excellent choice for
supplementary treatment in Type 2 diabetes. 


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Beneficial Effects of Broccoli Sprouts and Its Bioactive Compound Sulforaphane in Management of Type 2 Diabetes (pp. 225-238)