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Preclinical Studies On The Effect Of Sulforaphane On Cardiovascular Disease And Fetal Determinants Of Adult Health (pp. 209-224) $100.00
Authors:  (Ali Banigesh and Bernhard H.J. Juurlink, Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada, and others)
Abstract:
This chapter outlines some of the basic mechanisms, in particular oxidative stress
and inflammation that drive atherogenesis and hypertension. We review the experiments
where consumption of either glucoraphanin-rich broccoli sprouts or sulforaphane show a
decrease in oxidative stress and inflammation that is associated with: better blood
pressure, a decrease monocyte infiltration of blood vessels and better ability of hearts to
cope with ischemia and reperfusion. We also review the experiments that demonstrate
that a reduction in oxidative stress and inflammation accompanied by better blood
pressure have positive effects on fetal determinants of adult health and normalize the
kidney epigenome as determined by examining for global cytosine methylation. 


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Preclinical Studies On The Effect Of Sulforaphane On Cardiovascular Disease And Fetal Determinants Of Adult Health (pp. 209-224)