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Broccoli Sprout Supplementation As A Novel Method For Preventing Perinatal Brain Injury (pp. 161-184) $100.00
Authors:  (Jerome Y. Yager, Antoinette T. Nguyen, Jennifer Corrigan, Ashley M.A. Bahry, Ann-Marie Przyslupski, and Edward A. Armstrong, Department of Pediatrics, University of Alberta, Katz Group Centre for Pharmacy and Health Research, Edmonton AB, Canada, and others)
Abstract:
Cerebral palsy is the sine quo non phenotypical outcome measure of perinatal brain
injury. It continues to occur with an incidence of 2-3/1000 live births in term infants. The
incidence increases 10-fold in infants born prematurely, and yet another 10-fold in
developing countries. Risk factors causative for the development of cerebral palsy in
childhood predominantly occur during gestation, prior to the onset of labor and delivery,
whereas only 10-20% of causes occur as a result of a traumatic birth.
Despite these epidemiologic findings, efforts regarding the treatment of perinatal
brain injury are focused on rescue and/or rehabilitation. To address the majority of
causes, however, preventive therapies, provided during gestation, must be developed in
order to treat the ‘at risk’ fetus. Natural health products such as broccoli sprouts and its
active metabolite, sulforaphane, as potent phase-II enzyme inducers, show excellent
promise, given their safety and efficacy profile. In this chapter, we describe a host of preclinical
studies in rodent models of the human risk factors responsible for the majority of
causes of cerebral palsy in children. In this regard, we have utilized Broccoli Sprouts as a
dietary supplement during pregnancy, and shown it to prevent the behavioural and
pathological characteristics typical of perinatal brain damage. Our findings suggest this to
be a viable avenue for further exploration, and a potential safe and efficacious approach
for the prevention of perinatal brain injury and cerebral palsy. 


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Broccoli Sprout Supplementation As A Novel Method For Preventing Perinatal Brain Injury (pp. 161-184)