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Radiomitigating Potential of sulforaphane, A Constituent of Broccoli (pp. 145-160) $100.00
Authors:  (Paban K Agrawala and Omika Katoch, Paban K. Agrawala and Omika Katoch Department of Radiation Genetics and Epigenetics, Institute of Nuclear Medicine and Allied Sciences, Delhi, India)
Abstract:
Broccoli, a cole crop belonging to the cruciferae family, originated in Italy. Broccoli
is a nutrient powerhouse with phytochemicals such as dithiolthiones, s-methyl cysteine
sulfoxide, indole-3-carbinol, glucosinolates such as glucoraphanin, isothiocyanates,
indoles, etc. Broccoli is an excellent source of vitamins A (in the form of carotenoids),
B1, B3, B5, B6, B9, C, E, and K. It is also a very good source of calcium, chromium,
copper, iron, magnesium, manganese, phosphorus, potassium, selenium, zinc as well as
choline, omega-3 fatty acids and dietary fiber. Besides its nutritional properties, broccoli
also shows health benefits including cancer prevention, cholesterol reduction,
detoxification, anti-inflammatory effects and improved digestion. The isothiocyanate
sulphoraphane significantly suppresses oxidative stress and inflammation. Sulforaphane
and indole-3-carbinol present in broccoli have protective effects against cancer. These
phytochemicals boost detoxifying enzymes and promote expression of antioxidant
enzymes, thereby reducing oxidative stress. They also may affect estrogen levels which
may help reduce breast cancer risk. Recently we have shown that sulforaphane mitigates
radiation-induced DNA damage as studied in terms of micronuclei formation in human
lymphocytes following radiation administration. Sulforaphane also inhibited the rise in
histone deacetylase activity that normally is a consequence of irradiation. In this chapter
we discuss the ability of sulforaphane to increase the viability, using MTT, XTT and
CyQuant methods, of several cell types following radiation exposure. Estimation of
reactive oxygen species (ROS) formation using H2-DCF-DA fluorescent dye showed a
reduction in radiation-induced ROS levels in sulforaphane-treated group. 


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Radiomitigating Potential of sulforaphane, A Constituent of Broccoli (pp. 145-160)