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The NRF2 Signalling System (pp. 111-120) $100.00
Authors:  (Bernhard H.J. Juurlink, Bernhard H. J. Juurlink, Department of Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada)
Abstract:
This chapter gives a brief review of the Nrf2 signalling system and how it promotes
redox and metabolic homeostasis. Included is a description of many of the genes with
anti-oxidant response elements; the role of Keap1 and associated ubiquitin ligase
complex as well as the role of glycogen synthase 3β in regulating the half-life of Nrf2;
the role of Keap1 oxidation as well as phosphorylation of Nrf2 in Nrf2 signalling; the
newly discovered consequences of Nrf2 signalling such as promoting mitochondrial and
intermediary metabolism homeostasis; and finally, a caveat that promoting redox
homeostasis is not necessarily desired where cancer is involved. 


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The NRF2 Signalling System (pp. 111-120)