Authors: (Lida Sadeghinejad, Hossein Noyan, and Bernhard H. J. Juurlink, Department of Biomaterials, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada, and others)
Abstract: A brief overview of cellular oxidant production and scavenging is presented along
with the evidence for oxidative stress playing a role in aging. Oxidative stress is
associated with dysregulated kinase signalling and increased generalized inflammation.
The dysregulated kinase signalling that is also associated with increased NFkappaB
activation is likely due to oxidation of cysteine residues in protein and lipid phosphatases.
Although transient phosphatase inactivation is a normal part of many signal transduction
pathways an increase in overall oxidative stress will result in inappropriate spatial and
temporal activation of kinase signalling pathways, likely accounting for many of the
problems associated with aging such as an increase in generalized inflammation. Dietary
interventions that include increased cysteine intake and intake of Nrf2 activators that
promote the expression of dozens of anti-oxidant genes will decrease oxidative stress
resulting in more normalized cellular signalling.