Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Nutrition » Broccoli: Cultivation, Nutritional Properties and Effects on Health Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Criminal Justice: Government Policies and Programs
$73.80
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to The Xenobiotic Elimination System: An Overview (pp. 47-86)
Tell A Friend
 
Tell someone you know about this product.
The Xenobiotic Elimination System: An Overview (pp. 47-86) $100.00
Authors:  (Jane Alcorn, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada)
Abstract:
The chapter presents an overview of the xenobiotic elimination system from the
perspective of an oral xenobiotic exposure. It notes the interrelationship of the three
elimination organs, liver, kidney, and intestine, and their respective roles in limiting
systemic exposures. The polarized epithelia of each elimination organ are highlighted as
these are the ‘workhorses’ of xenobiotic elimination and express the transporters and
enzymes that ultimately cause xenobiotic removal from the body. Emphasis is placed on
the four phases of xenobiotic elimination, phase 0 transporter-mediated xenobiotic uptake
into the polarized epithelia, phase I and phase II xenobiotic metabolism within the
polarized epithelia, and phase III transporter-mediated xenobiotic efflux from the
polarized epithelium. Hence, the chapter provides a general summary of the solute carrier
transporters of phase 0 elimination, the cytochrome P450 enzymes of phase I metabolism,
the conjugating enzymes of phase II metabolism, and the ATP binding cassette
transporters of phase III elimination. Finally, it offers an overview of the genetic,
environmental, and host factors influencing the activity of these individual elimination
mechanisms, as well as the transcriptional factors that regulate and coordinate their
expression. An extensive interplay between the various xenobiotic elimination
mechanisms requires that the xenobiotic is positioned within an integrated xenobiotic
elimination system to truly understand xenobiotic exposure outcomes. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Flavonoids in the Fight against Upper Gastrointestinal Tract Cancers
02.Resilience and Health: A Potent Dynamic
03.Alpha Lipoic Acid: New Perspectives and Clinical Use in Obstetrics and Gynecology
04.Advances in Psychobiology
05.Biodiversity in Time and Space
06.Multifaceted Autoethnography: Theoretical Advancements, Practical Considerations and Field Illustrations
07.Islam and Muslims in Europe
08.Violence Against Women in the 21st Century: Challenges and Future Directions
09.Challenges and Opportunities for Eurozone Governance
10.Flour: Production, Varieties and Nutrition
11.Liquid Metals: From Atomistic Potentials to Properties, Shock Compression, Earth's Core and Nanoclusters
12.Polyunsaturated Fatty Acids (PUFAs): Food Sources, Health Effects and Significance in Biochemistry

Nova Science Publishers
© Copyright 2004 - 2018

The Xenobiotic Elimination System: An Overview (pp. 47-86)