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01.Gene Silencing: New Research
02.New Research on DNA Damage
03.Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
04.MicroRNA let-7: Role in Human Diseases and Drug Discovery
05.Myelin Basic Protein
06.New Research on Genomic Instability
07.Developmental Gene Expression Regulation
08.Lecture Notes on Computational Mutation
09.Fragile Sites: New Discoveries and Changing Perspectives
10.Progress in Stem Cell Applications
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DNA Methylation Research Trends
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Editors: Taku B. Kobayashi
Book Description:
DNA methylation is a type of chemical modification of DNA that can be inherited without changing the DNA sequence. As such, it is part of the epigenetic code and is the most characterized epigenetic mechanism. DNA methylation involves the addition of a methyl group to DNA — for example, to the number 5 carbon of the cytosine pyrimidine ring. DNA methylation is probably universal in eukaryotes. In humans, approximately 1% of DNA bases undergo DNA methylation. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide. The methylation status of specific cytosines can be determined using methods based on bisulfite sequencing. This book presents new and important research from around the world in this field.

Table of Contents:

Chapter I - Investigation of the CpG Effect in Mammalian Genomes; pp. 1-24
(Zhongming Zhao, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth Univ., Richmond, VA, Center for the Study of Biological Complexity, Virginia Commonwealth Univ., Richmond, VA, Cizhong Jiang, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth Univ., Richmond, VA)

Chapter II - CpG Islands in Plants; pp. 25-41
(Ikuo Ashikawa, National Institute of Crop Science, Ibaraki, Japan)

Chapter III - Epigenetic Roles of CpG Methylation at Non-CpG-Islands revealed by Morphology-Oriented Epigenetic Research; pp. 43-66
(Sohei Kitazawa, Kiyoshi Mori, Takeshi Kondo, Division of Molecular Pathology, Dept. of Biomedical Informatics, Kobe Univ. Graduate School of Medicine)

Chapter IV - DNA Methyltransferase Inhibitors as Therapeutic Agents in Hematological Malignancies; pp. 67-85
(Takashi Kumagai, Dept. of Hematology, Ohme Municipal General Hospital, Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine)

Chapter V - Analysis of DNA Methylation Patterns for the Early Diagnosis, Classification and Therapy of Human Cancers; pp. 87-133
(Jorg Tost, Laboratoire d'Epigenetique, Centre National de Genotypage, Evry, France)

Chapter VI - DNA Methylation Changes in Pathogenesis and Therapy of Hematopoietic Malignancies; pp. 135-182
(Edgar Jost, Rainhardt Osieka, Oliver Galm, Medizinische Klinik IV, Univ. Aachen, Aachen, Germany)

Chapter VII - DNA Methylation and Tumor Suppression; pp. 183-208
(Iftikhar Qayum, Women Medical College, Abbottabad, Pakistan)

Chapter VIII - Methylation and Loss of Heterozygosity in Cancer are linked by siRNA?; pp. 209-236
(Coral Wynter, Marcelo Alfonzo, Itala Lippo de Becemberg, Seccion de Biomembranas, Instituto de Medicina Experimental, Univ. Central de Venezuela, Caracas, Venezuela)

Chapter IX - Methylation in Cancer Research; pp. 237-259
(Juan Carlos Roa S., Patricia Garcia M., Dept. of Pathology, Univ. de La Frontera, Temuco, Chile)


   Binding: Hardcover
   Pub. Date: 2007
   ISBN: 1-60021-721-4
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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