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Alzheimer's Disease Research Trends
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Editors: A. P. Chan
Book Description:
Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. The most common form of dementia among older people is Alzheimer's disease (AD), which involves the parts of the brain that control thought, memory, and language. Age is the most important known risk factor for AD. The number of people with the disease doubles every 5 years beyond age 65. AD is a slow disease, starting with mild memory problems and ending with severe brain damage. The course the disease takes and how fast changes occur vary from person to person. On average, AD patients live from 8 to 10 years after they are diagnosed, though the disease can last for as many as 20 years.
Current research is aimed at understanding why AD occurs and who is at greatest risk of developing it, improving the accuracy of diagnosis and the ability to identify those at risk, discovering, developing, and testing new treatments, and discovering treatments for behavioral problems in patients with AD. This new book gathers state-of-the-art research from leading scientists throughout the world which offers important information on understanding the underlying causes and discovering the most effective treatments for Alzheimer's Disease. This new book presents leading-edge research advances from around the world.

Table of Contents:
Preface

Expert Commentaries

Commentary A - Alzheimer's Disease: The Calmodulin Connection and B-Amyloid; pp. 1-10
(Danton H. O'Day, Dept. of Biology, Univ. of Toronto at Mississauga, Mississauga, Ontario, Michael A. Myre, MassGeneral Institute for Neurodegenerative Disease, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA)

Chapter I - Alzheimer's Disease- 100 Years of Research; pp. 11-15
(Walter J. Lukiw, Louisiana State Univ. Health Science Center, New Orleans, LA)

Chapter II - Evidence-based Care Intervention Aimed at Reducing Behavioral and Psychological Symptoms of Dementia (BPSD) amond Elderly with Dementia using the Progressively Lowered Stress Threshold Model; pp. 17-22
(Masao Kanamori, Biwako Sport College, Seikei Univ., Japan)

Chapter III - Polymer Templates have an Organizing Effect on AB Aggregation; pp. 23-56
(Norbert W. Seidler, Randal C. Michelson, Dept. of Biochemistry, Kansas City Univ. of Medicine and Biosciences, Kansas City, Missouri)

Chapter IV - Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter targeting Potential Agents for Alzheimer's Disease;
pp. 57-89
(Narihiro Toda, Tsugio Kaneko, Hiroshi Kogen, Exploratory Chemistry Research Laboratories, R & D Strategy Dept., Tokyo, Japan)

Chapter V - Early Onset Dementia with Abundant Non-Neuritic AB Plagues and without Significant Neuronal Loss: Report of Two Japanese Autopsy Cases; pp. 91-116
(Osamu Yokota, Kuniaki Tsuchiya, Shigetoshi Kuroda, Dept. of Neuropsychiatry, Okayama Univ. Graduate School of Medicine, Okayama, Japan)

Chapter VI - Alzheimer's Disease; pp. 117-146
(Maria Luiza Mamede-Rosa)

Chapter VII - Volumetric Differences of Hippocampal Volume Effect fMRI Differences in the Brain Functional Activation for Alzheimer's Disease Patients during Memory Encoding; pp. 147-173
(Alfonso Barros-Loscertales, Dept. Psychology, Univ. Jaume I, Castellon, Spain, Vicente Belloch-Ugarte, Hospital Arnau de Vilanova, Valencia, Spain, Rosella Mallol, Neurology Unit, Hospital La Magdalena, Castellon, Spain)

Chapter VIII - Protective Effect on Vitamin C on Okadaic Acid-Induced Oxidative Stress and Cytoskeletal Alterations in an In Vitro Model similar to Alzheimer's Disease in N1E-115 Neuroblastoma Cells; pp. 175-192
(Isaac Tunez, M. del Carmen Munoz, Pedro Montilla, Dept. of Biochemistry and Biology Molecular, School of Medicine, Univ. of Cordoba, Cordoba, Spain)

Chapter IX - Focus on Dementia associated with Parkinson's Disease: The Role of Cholinesterase Inhibitors; pp. 193-208
(Carmine Fuschillo, Dept. of Mental Health, Neuropsychogeriatric Ward, Naples, Italy, Vincenzo Canonico, Alzheimer Evaluation Unit, Univ. of Naples "Federico II", Naples, Italy)

Chapter X - A Comparison with Writing Alterations in Alzheimer's Patients; pp. 209-223
(Rita Moretti, Paola Torre, Rodolfo M. Antonello, Dipart. di Medicina Clinica e Neurologia, Univ. degli Studi di Trieste)

Chapter XI - The Role of Alleles 4 and 2 of the APOE Gene and Cognitive Tests in The Early Conversion of Mild Cognitive Impairment to Alzheimer Dementia; pp. 225-239
(Ana Barabash, Dept. of Psychiatry, Alberto Marcos, Dept. of Neurology, Ines Ancin, Dept. of Psychiatry, Hospital Clinico San Carlos, Madrid, Spain)

Chapter XII - Neuroinflammatory Onset Dynamics and Progression in Alzheimer Disease; pp. 241-251
(Lawrence M. Agius, Dept. of Pathology, St. Luke's Hospital Gwardamangia, Univ. of Malta Medical School, Msida, Malta, Europe)

Chapter XIII - Effects of Dietary Docosahexaenoic Acid on Spatial Cognition of Normal and Alzheimer's Disease Model Rats; pp. 253-273
(Michio Hashimoto, Dept. of Environmental Physiology, Shimane Univ. Faculty of Medicine, Shimane, Japan, Shahdat Hossain, Dept. of Environmental Physiology, Shimane Univ. Faculty of Medicine, Shimane, Japan, Dept. of Biochemistry and Molecular Biology, Jahangirnagar Univ., Bangladesh)

Chapter XIV - Navigational Disorders in Patients with Alzheimer's Disease; pp. 275-288
(Ming-Chyi Pai, Division of Behavioral Neurology, Dept. of Neurology, National Cheng Kung Univ. Hospital, Tainan, Taiwan, W. Jake Jacobs, Dept. of Psychology, the Univ. of Arizona, Tucson)

Index

   Binding: Hardcover
   Pub. Date: 2008
   ISBN: 1-60021-712-5
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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