Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Nutrition » Vitamin D: New Research chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Human Lyme Neuroborreliosis
$160.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Bestsellers
01.High Levels of Active 1,25-Dihydroxyvitamin D Despite Low Levels of the 25-Hydroxyvitamin D Precursor - Implications of Dysregulated Vitamin D for Diagnosis and Treatment of Chronic Disease (pp. 1-23)
02.Prenatal Vitamin D Deficiency and Brain Development (pp. 153-173)
Notifications more
NotificationsNotify me of updates to High Levels of Active 1,25-Dihydroxyvitamin D Despite Low Levels of the 25-Hydroxyvitamin D Precursor - Implications of Dysregulated Vitamin D for Diagnosis and Treatment of Chronic Disease (pp. 1-23)
Tell A Friend
 
Tell someone you know about this product.
High Levels of Active 1,25-Dihydroxyvitamin D Despite Low Levels of the 25-Hydroxyvitamin D Precursor - Implications of Dysregulated Vitamin D for Diagnosis and Treatment of Chronic Disease (pp. 1-23) $25.00
Authors:  J. C. Waterhouse , Trevor G. Marshall, Belinda Fenter, Meg Mangin and Greg Blaney (The Stillpoint Project, Vancouver, Canada)
Abstract:
The active secosteroid hormone 1,25-dihydroxyvitamin-D (1,25D) often reaches excessive levels in normocalcemic patients suffering from chronic Th1 inflammatory illnesses, including sarcoidosis and rheumatoid arthritis. This is due to unregulated production of 1,25D in the mitochondria of activated macrophages. Phagocytic cells parasitized by cell wall deficient (CWD) L-forms of bacteria drive this dysfunction of vitamin D metabolism. The paracrine levels of 1,25D rise and the level of substrate 25-D falls. If studies measure only the 25D precursor, a low 25D may be misinterpreted as indicating the patient requires vitamin D supplementation. Our data show that active 1,25D hormone may be elevated, even with a low level of 25D substrate because of the inflamed macrophages’ hyperactive conversion to the active hormone. In sarcoidosis, for example, this dysregulated vitamin D conversion can mean that even a moderate intake of vitamin D through ingestion or solar exposure can cause the 1,25D hormone to become high enough to stimulate osteoclastic action, and bone resorption. Data presented here suggest that this extra-renal synthesis of 1,25D is more widespread than previously thought and because it leads to vitamin D hypersensitivity, has important implications for research, diagnosis and treatment of chronic disease. The relationship of our data to past research on the role of vitamin D in several diseases is discussed. The assay of both the active 1,25D and inactive 25D metabolites will lead to additional clinical data, potentially improving both diagnosis and care of a variety of autoimmune and other Th1 illnesses. The high recovery rate using a new antibacterial protocol (initially developed for treating sarcoidosis) and the normalization of 1,25D levels, subsequent to such treatment, emphasizes the importance of measuring both the active 1,25D hormone and the 25D substrate. It should be noted that serum must be properly handled and transported frozen in order to obtain accurate 1,25D test results. Further, an increase in 25D levels induced by vitamin D supplementation may lead to long-term disease progression by facilitating proliferation of the intracellular CWD bacterial pathogens. 


Available Options:
Version:
Customers who bought this product also purchased

Prenatal Vitamin D Deficiency and Brain Development (pp. 153-173)

Is Calcidiol an Active Hormone? (pp. 1-28)
Special Focus Titles
01.Biomarker Discovery and Biotherapeutics Applications of Photosynthetic Light-Harvesting and Bioluminescence Light-Emitting Chromophore-Protein Complexes in Stem Cell Biology and Regenerative Medicine.
02.Music and Hearing
03.The Mind of the Artist: Attention Deficit Hyperactivity Disorder, Autism, Asperger Syndrome & Depression
04.Interviews with Professor Donald Elder: The Presidents of the United States
05.Einstein and Others: Unification
06.War: An Introduction to Theories and Research on Collective Violence, 2nd Edition
07.Gambling: Cultural Attitudes, Motivations and Impact on Quality of Life
08.Autonomy, Altruism and Authority in Medical Ethics: Essays in Honor of Professor Shimon Glick
09.Child and Adolescent Health Issues (A Tribute to the Pediatrician Donald E Greydanus)
10.Beyond Diet and Depression, Volume 1: Basic Knowledge, Clinical Symptoms and Treatment of Depression
11.Research on Online/Offline Interventions in Mental Health: A Critical Review
12.Marine Oils (From Sea to Pharmaceuticals)
13.Cervical Spine Injuries: Epidemiology, Long-Term Outcomes and Complications
14.New Research Trends of Fluorite-Based Oxide Materials: From Basic Chemistry and Materials Science to Engineering Applications

Nova Science Publishers
© Copyright 2004 - 2015

High Levels of Active 1,25-Dihydroxyvitamin D Despite Low Levels of the 25-Hydroxyvitamin D Precursor - Implications of Dysregulated Vitamin D for Diagnosis and Treatment of Chronic Disease (pp. 1-23)