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Experimental Leukemia: History, Biology and Genetics
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Authors: Taketoshi Sugiyama (Kobe University, Kobe, Japan) 
Book Description:
The world of experimental leukemia research is a miniature of cancer research. Cancer research started from experimental leukemia/sarcoma research of Ellermann and Bang and Peyton Rous in early 1900s. Experimental leukemia includes most of important elements of cancer research; both viral and chemical carcinogenesis; most of important oncogenes and suppressor genes and the related cell biology. The author has added only a few sections such as skin carcinogenesis done by Yamagiwa and Berenblum and DNA viruses from outside of experimental leukemia. By doing this, this book covers most of important topics of modern oncology, except researches done on human cancers.

In this book, the author has arranged the chapters to contrast the pioneer works by Peyton Rous, Jacob Furth, and Ludwik Gross, etc, done more than half a century ago and the recent works by molecular biologists. Although the former pathologists provided various experimental materials, faced to severe criticism by contemporary researchers and they had tough hearts to cope with them, molecular biologists solved questions on these materials step by step by disclosing the invisible molecular events as a visible charts, molecular diagrams, or 3-D models just as magicians do. Experimental leukemia has always afforded the key materials for solution of cancer.

In experimental leukemia, mutations and genetic recombination play an important role. They include ras gene mutations, insertional mutagenesis and gene transduction by retroviruses, recombination among retroviruses, and chromosome translocations. Most of them occur in highly specific genomic sites. However, the reason for the specificity in target sites remained obscure. The author was especially interested in the common target genomic sites for chemical carcinogens and retroviruses. Therefore the common pathway for retroviruses and chemicals became one of the main topics of this book.

Table of Contents:
Preface

Chapter 1. Background of Experimental Leukemia Research, pp. 1-14
1.1 Classic Pathology
1.2 Classic Cancer Biochemistry, 1920-1970
1.3 Concept of Gene 1940-1970
1.4 Cell and Genome Analysis 1950-1980
1.5 Discoveries in Retroviral Oncology Started in 1960
1.6 Oncongenic DNA Viruses
1.7 Computers and Gene Mapping
1.8 DNA Data Bases and Genome Projects
1.9 New Genetic Leukemia Models
1.10 Merits of Experimental Leukemia Research
1.11 "Business of Discovery," a Cumulative Chain Process of Hypothesis and Evidence

Chapter 2. Early History of Leukemia Research, pp. 15-71
2.1 Discovery of Human Leukemia
2.2 Spontaneous Animal Leukemia and Venereal "Lymphosarcoma"
2.3 Avian Leukosis
2.4 Rous Sarcoma
2.5 Fujinami Sarcoma Another Avian Sarcoma Strain
2.6 Marek Disease
2.7 Development of Inbred Mice
2.8 Jacob Furth and Mouse Strain Ak (AKR)
2.9 Search for Leukemia Virus (Ludwik Gross)
2.10 Early History of Chemical Leukemogenesis

Chapter 3. Avian Sarcoma and Leukosis Viruses, and Canine TVT, pp. 73-119
3.1 Rous Sarcoma Virus (RSV)
3.2 Fujinami Sarcoma Virus (FSV)
3.3 Avian Myeloblastosis Virus (AMV)
3.4 Avian Erythroblastosis Virus (AEV)
3.5 Avian Myelocytomatosis Virus (MC29)
3.6 Avian Leukemia Virus (ALV)
3.7 Marek Disease Virus (MDV)
3.8 Canine Transmissible Venereal Tumor (CTVT or TVT)

Chapter 4. Mouse Leukemia Viruses, pp. 121-193
4.1 Gross Passage-A Virus (MLV, Gross or AKR Virus)
4.2 Graffi Leukemia Virus (Gr-MLV)
4.3 Friend Leukemia Virus (F-SFFV and F-MLV)
4.4 Rauscher Murine Leukemia Virus (R-MLV)
4.5 Moloney Murine Leukemia Virus (Mo-MLV)
4.6 Abelson Murine Sarcoma/Leukemia Virus (Ab-MSV/MLV)
4.7 Murine Sarcoma Viruses

Chapter 5. Leukemia Induced by Chemicals and Radiations, pp. 195-239
5.1 Chemically Induced Mouse Leukemia
5.2 Mineral-Oil-Induced Plasmacytoma of the Mouse
5.3 Radiation Leukemia Virus (Kaplan Rad-LV)
5.4 Chemical Leukemogenesis in the Rat

Chapter 6. Experimental Studies on Stem Cellsand Cytokines, pp. 241-250
6.1 Early Studies on Stem Cell Colonies by McCulloch and Till (1960)
6.2 Nurse Cells in Bone Marrow (Bessis, 1958) and in Thymus (Wekerle, 1980)
6.3 Colony Stimulating Factors
6.4 Cell Differentiation Therapy

Chapter 7. Retroviruses and Carcinogens: Interactions with Genome, pp. 251-312
7.1 Virus Tropism, Host Range Determinant (SU/Env), and Virus Entry
7.2 Insertional Mutagenesis
7.3 Genomic Targets of Retroviruses
7.4 Chromosome Actions of Carcinogenic Chemicals, Radiations and Viruses
7.5 Chemical Carcinogen Interactions with DNA
7.6 HS Sites and Chromatin Remodeling by Gene Activation
7.7 Conclusive Note: The HS sites are Common Targets of Chemicals, Viruses, and Radiations

Chapter 8. Cell Cycle Control and Centrosome in Leukemia, pp. 313-331
8.1 Chromosomal and Centrosomal Abnormalities in Cancer Cells
8.2 Function, Structure and Molecular Components of the Centrosome
8.3 Centrioles, Replication, and its Control
8.4 Control of Cell Cycles and Checkpoints
8.5 Centrosomal Abnormalities as a Cause of Chromosomal Abnormalities in Cancer Cells
8.6 On Molecule Interaction on Rb and p53 Cell Cycle Proteins
8.7 Centriole as the Control Center of a Cell

Epilogue, pp. 333-335
References, pp. 337-441

Index

   Binding: Hardcover
   Pub. Date: 2009
   Pages: 7 x 10, 460 pp.
   ISBN: 978-1-60021-497-4
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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