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01.Gene Silencing: New Research
02.New Research on DNA Damage
03.Life Span Development in Genetic Disorders: Behavioral and Neurobiological Aspects
04.MicroRNA let-7: Role in Human Diseases and Drug Discovery
05.Myelin Basic Protein
06.New Research on Genomic Instability
07.Developmental Gene Expression Regulation
08.Lecture Notes on Computational Mutation
09.Fragile Sites: New Discoveries and Changing Perspectives
10.Progress in Stem Cell Applications
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Signal Transduction Research Trends
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Editors: Nickolas O. Grachevsky
Book Description:
Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Table of Contents:

Chapter 1 - Foiling Drug Resistance with Targeted Therapeutics- Principles and Challenges in a New Era of Cancer Therapy; pp. 1-16
(Catherine A. O'Brian, Feng Chu (Anderson Cancer Center,
Houston, TX), and Ahmad R. Safa (Dept. of Pharmacology and Toxicology, Indiana Univ. Cancer Center, Indiana Univ. Sch. of
Medicine,Indianapolis, IN)

Chapter 2 - Estrogen Signal Transduction Pathways from Plasma Membrane to the Nucleus; pp. 17-44
(Maria Marino and Francesco Caiazza (Dept. of Biology, Univ. Roma Tre, Rome, Italy)

Chapter 3 - The Peptide Strategy as a New Approach to the Study of G Protein-Coupled Signaling Systems; pp. 45-93
(Alexander O. Shpakov, Marianna N. Pertseva, Laboratory of Molecular Endocrinology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia)

Chapter 4 - Cadhernin Signaling in Vascular Cells: T-Cadherin is a New Player; pp. 95-129
(K.A. Rubina, N.I. Kalinina, V.A. Tkachuk (Fac. of Fundamental
Medicine, Lomonosov Moscow State Univ., Moscow, Russia),and Ye. V. Parfyonova (Russian Cardiology Research and Prod. Center, Moscow, Russia)

Chapter 5 - Time Windows of Hedgehog Signaling in the Craniofacial and Vascular Development: Analyses using Mouse Whole Embryo Culture System; pp. 131-170
(Takashi Nagase (Clin. Research Center, Nat. Hosp. Org. Murayama Med. Center, Gakuen, Musashimurayama-shi, Tokyo, Japan) and Miki Nagase (Dept. of Nephrology and Endocrinology, Univ. of Tokyo Grad. Sch. of Medicine, Hongo, Tokyo, Japan)

Chapter 6 - The Ror2 Receptor Tyrosine Kinase; pp. 171-186
(Julia Billiard, Barry S. Komm, and Peter V.N. Bodine, Women’s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA, USA)

Chapter 7 - Nuclear Calcium Signaling: The Nuclear Envelope Store and the Regulation of Transcription; pp. 187-205
(Carlos Escande, Paula Arbildi, Eduardo Chini (Dept. of Anesthesiology, Mayo Clinic, Rochester, Minnesota), and Juan Claudio Benech (Dept. de Proteinas y Acidos Nucleicos, Inst. de Investigaciones Biologicas, Montevideo, Uruguay), (Fac. de Veterinaria, Univ. de la Republica, Montevideo, Uruguay)

Chapter 8 - Regulation of Extracellular Signal Communications at the Cortical Network Level by Intracellular Signal Communications in the Brain; pp. 207-220
(Hiroshi Yoshimura (Dept. of Oral and Maxillofacial Surgery, Kanazawa Med. Univ., Uchinada-cho, Japan)

Chapter 9 - New Research on Signal Transduction in Response to Bacteroides Fragilis Enterotoxin; pp. 221-248
(Jung Mogg Kim (Dept. of Microbiology, Hanyang Univ. Coll. of Medicine, Seoul, South Korea)

Chapter 10 - Innate Immune Signaling Pathways and Viral Recognition: New Perspectives; pp. 249-263
By Ismar R. Haga and Andrew G. Bowie (Sch. of Biochemistry and Immunology, Trinity Coll. Dublin, Dublin, Ireland)

Chapter 11 - Neurosignaling Mechanisms and Environmental-Induced Neurobiological Activities; pp. 265-291
(Marcello Canonaco, Raffaella Alo, Giuseppina Giusi, and Rosa Maria Facciolo (Comparative NeuroAnatomy Lab., Ecology Dept., Univ. of Calabria, Arcavacata di Rende, Italy)


   Binding: Hardcover
   Pub. Date: 2007
   ISBN: 1-60021-487-8
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Signal Transduction Research Trends