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Medicine Research Summaries (with Biographical Sketches). Volume 17
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Authors:  (Morten L. Kringelbach, Alexander L. Green, Erlick A.C. Pereira, Sarah L.F. Owen and Tipu Z. Aziz)
Abstract:
As a clinical intervention, deep brain stimulation (DBS) has
provided remarkable therapeutic benefits for otherwise
treatment-resistant movement and affective disorders
including chronic pain. In this review, we concentrate on
the experience of using DBS to treat chronic pain in
Oxford. We provide a brief historical background as well as
details of our methods for patient selection, surgical
techniques and assessment. While the precise mechanisms
of action for DBS remain uncertain, we describe how DBS
can help for treatment-resistant chronic pain and have great
potential to advance our general understanding of the
human brain. In particular, we show how DBS can be used
in conjunction with methods such as local field potentials
and magnetoencephalography to map the underlying
mechanisms of normal and abnormal oscillatory
synchronization in the brain related to the pleasure of pain
relief. 


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Deep brain stimulation for chronic pain (pp. 301-314)