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Curcumin: Synthesis, Emerging Role in Pain Management and Health Implications
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Editors: Daniel Loïc Pouliquen (Centre de Recherche en Cancérologie Nantes Angers (CRCNA), Institut de Recherche en Santé de l’Université de Nantes (IRS-UN), France)
Book Description:
Examples of plant-derived pharmaceuticals that have become the focus of continuous and exponential research and development interest have, to date, been somewhat scarce. After a long period, the last two decades have been characterized by a 100-fold increase in the number of scientific articles published annually that are of relevance to the use of curcumin in biomedicine. Today, the already-wide spectrum of potential clinical applications of this natural drug and its synthetic derivatives continues to grow, including chemoprevention and the treatment of cancers, inflammatory and immune diseases, diabetes, bacterial and viral infections, parasitosis, and cardiovascular and neurodegenerative diseases.

Over the last two decades, numerous findings have confirmed the safety of curcumin, both in preclinical and clinical studies. Its physicochemical properties, low bioavailability and rapid metabolism have, however, somewhat limited its potential therapeutic applications. To overcome these limitations, the last few years have seen an impressive development of research on analogs, prodrugs and nanostructured systems, a number of which are already demonstrating improved properties compared with the parent structure. In parallel, new administration routes have been explored, and additional pharmacological properties have been documented, leading in particular to promising prospects for pain management.

This is the first book devoted to all of these aspects of research. It comprises 20 chapters (by 71 contributors) with 32 tables, 100 figures and about 2000 references, organized into three sections, with a progression from basic sciences to clinical applications. The first section relates to photophysical and photochemical properties, structure-activity relationships, the design of curcumin derivatives, its biological targets and pharmacology, prodrug concepts, and the development of nanoformulations of curcumin. The second section covers the exploration of the antinociceptive role of curcumin and its clinical applications for pain management, treatment of neurological diseases and burn wounds, its anti-inflammatory and immunomodulatory properties, and its pharmacological effects for the treatment of parasitosis. The third section describes various aspects of the antitumor activities of curcumin and emerging therapeutic strategies using this drug and its many derivatives.

The various chapters of this book have been written by experts from five continents, representing 15 countries and 33 teams, who have agreed to present their viewpoints and experience in this field. It provides a systematic reference source for scientists, clinical researchers and students who wish to become familiar with the different areas of investigation in the subject. (Imprint: Nova Biomedical)

Table of Contents:
Preface pp.ix-xi

Part I: Physical and Chemical Properties, Structure-Activity, Biological Targets, Synthesis of Derivatives and Prodrugs, and Development of Nanoformulations pp.1-2

Chapter 1. Photophysical and Photochemical Aspects of Curcumin
(Yuval Erez and Dan Huppert, Faculty of Exact Sciences, School of Chemistry, Tel Aviv, and Department of Physics of Complex Systems,
Weizmann Institute of Science, Rehovot, Israël) pp.3-48

Chapter 2. Elucidating the Structure-Activity Relationship of Curcumin and Its Biological Activities
(Chanin Nantasenamat, Saw Simeon, Abdul Hafeez, Veda Prachayasittikul, Apilak Worachartcheewan, Napat Songtawee, Kakanand Srungboonmee, Chartchalerm Isarankura-Na-Ayudhya, Supaluk Prachayasittikul and Virapong Prachayasittikul, Faculty of Medical Technology Mahidol University, Mahidol University, Bangkok, Thailand)
pp.49-86
Chapter 3. Curcumin Derivatives: Aβ-Ligands As Potential Diagnostic and Therapeutic Tools for Alzheimer’s Disease
(Barbara La Ferla, Cristina Airoldi and Giuseppe D’Orazio, Dept of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, Italy)pp.87-102

Chapter 4. Biological Targets and Pharmacology of Curcumin
(Asma El-Magboub, Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero and Ian S. Haworth, Dept. of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, and University of Southern California, Los Angeles, USA)pp.103-134

Chapter 5. Design, Synthesis and Biological Activities of Curcumin Prodrugs
(Pornchai Rojsitthisak, Wisut Wichitnithad, Chawanphat Muangnoi, Asma El-Magboub, Rebecca M. Romero and Ian S. Haworth, Dept. of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, and University of Southern California, Los Angeles, USA)pp.135-176

Chapter 6. Nanoencapsulated Curcumin: In Vivo Findings of Its Implications for Human Health
(Karine Coradini, Diego Fontana de Andrade and Ruy Carlos Ruver Beck, Federal University of Rio Grande do Sul, Faculty of Pharmacy, Porto Alegre, RS, Brasil)pp.177-210

Part II: Pain Management, Anti-Inflammatory and Immunomodulatory Properties, and Antiparasitic Effects pp.211-212

Chapter 7. Therapeutic Role of Curcumin in Neurological Diseases and Pain Management
(Adeeb Shehzad and Young Sup Lee, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu,
South Korea)pp.213-236

Chapter 8. Challenges and Opportunities in Developing Curcumin for Chronic Pain Management
(Zhongfa Liu, Division of Pharmaceutics and Pharmaceutic Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA)
pp.237-254
Chapter 9. Analgesic and Anti-Inflammatory Properties of Curcumin: Application for Burn Wounds
(Margaux M. Salas, Bopaiah P. Cheppudira, Marcie Fowler, Lawrence Petz, David I. Devore and John L. Clifford, Battlefield Pain Management Research Program, United States Army Institute of Surgical Research, Fort Sam Houston, Texas, US)pp.255-280

Chapter 10. Curcumin and Inflammation: The Role of Neutrophils
(Francis Antoine and Denis Girard, INRS-Institut Armand-Frappier, Research Laboratory in Inflammation and Physiology of Neutrophils, Laval, Québec, Canada)pp.281-296

Chapter 11. Role of Curcumin on Asthma: Route of Administration and Immunomodulation
(Rashmi Singh, Department of Zoology, MMV, Banaras Hindu University, Varanasi, India)pp.297-316

Chapter 12. Curcumin: A Natural Drug with Interesting Pharmacological Effects for the Treatment of Parasitosis
(Enyara Rezende Morais, Julia Medeiros Souza and Lizandra Guidi Magalhães, Institute of Genetics and Biochemistry, Federal University of Uberlândia, Campus Patos de Minas, Patos de Minas, MG, and Research Center in Exact and Technologic Sciences, University of Franca, Franca, SP, Brasil)pp.317-328

Part III: Antitumor Activities, Emerging Therapeutic Strategies for Cancer Treatment with Curcumin and Its many Derivatives pp.329-330

Chapter 13. Role of Curcumin in Cancer Therapy: Radioprotecting and Radiosensitizing Properties
(Natividad Sebastià, Alegria Montoro, Carla Soler, Regina Rodrigo, Jesús Blesa, Juan Ignacio Villaescusa and José Miguel Soriano, Radiation Protection Service, “La Fe” Polytechnic and University Hospital, Valencia; Mixt Unit of Investigation in Endocrinology and Clinical Nutrition, Biomedical Imaging Investigation Group, and Research Group on Sensorineural Diseases, IIS, Health Research Institute and University Hospital La Fe, and Department of Preventive Medicine and Public Health, Faculty of Pharmacy, University of Valencia, Burjassot; Valencia, Spain)pp.331-346

Chapter 14. Curcumin Analogues for the Treatment of Breast Cancer Revisited: The Nanotechnology Approach
(Vignesh Sundararajan, Rhonda J. Rosengren and Khaled Greish, Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand, and Dept of Oncology, Faculty of Medicine, Suez Canal University, Egypt)pp.347-378

Chapter 15. Curcumin Analogs and Combination Therapies Open Promising Prospects for Cancer Treatment
(Kuen-Tyng Lin, Yuh-Shan Jou, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan)pp.379-394

Chapter 16. Glorious Past and Promising Future of Curcumin-Based Antitumor Therapeutic Strategies
(Naveen Kumar Vishvakarma, Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Chhattisgarh, India)pp.395-408

Chapter 17. Curcumin: A Broad Spectrum Inhibitor Targeting Pathways Relevant to Glioblastomas
(Alfeu Zanotto-Filho, Alexander James Roy Bishop and José Cláudio Fonseca Moreira, Dept. of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Brasil, and Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, USA)pp.409-434

Chapter 18. New Prospects with Curcumin in the Treatment of Mesothelioma: Lessons from an Orthotopic Rat Tumor Model
(Daniel L. Pouliquen, Béatrice Nawrocki-Raby, Amal Ouacher, Cécile Deleine, Stéphanie Blandin, Myriam Robard, Philippe Birembaut, Marc Grégoire, UMR 892 Inserm / 6299 CNRS (CRCNA), Plate-forme MicroPICell, SFR François Bonamy, Institute of Health Research of Nantes University (IRS-UN), University of Nantes, Nantes and UMRS 903 Inserm and Laboratory of Histology, CHU Reims, University of Reims Champagne Ardenne, France)pp.435-456

Chapter 19. Curcumin Suppresses Angiogenesis, Invasion and Metastasis through Inhibiting Matrix Metalloproteinases in Human Cancers
(Thian-Sze Wong, Wei Gao, Yu-Wai Chan, Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR)pp.457-470

Chapter 20. Curcumin As a Potential New Therapeutic Approach against Oral Cancer
(Dan Dayan, Ayelet Zlotogorski-Hurvitz, Aliza Dayan, Tuula Salo, and Marilena Vered, Department of Oral Pathology and Oral Medicine, School of Dentistry, Tel Aviv University, Tel Aviv, Israel, and others)pp.471-488

Index pp.491-517



   Series:
      Pharmacology - Research, Safety Testing and Regulation
   Binding: Hardcover
   Pub. Date: 2014 - 3rd Quarter
   Pages: 528. 7x10 - (NBC-C)
   ISBN: 978-1-63321-319-7
   Status: AV
  
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PP Page Proofs
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Curcumin: Synthesis, Emerging Role in Pain Management and Health Implications