Neonatal asphyxia and stroke: morbidity, models, consequences, and treatments (pp. 89-110)
Authors: (J. R. Rivers and J.C. Ashton, Department of Pharmacology and Toxicology, University of Otago,Dunedin, New Zealand)
Abstract: Neonatal and early childhood asphyxia is a major cause of morbidity and chronic
cognitive dysfunction. In developed countries approximately births per 1000 have
asphyxia related complications including encephalopathy.
In this chapter we will discuss the burden of neonatal asphysxia and stroke, and the
neurological consequences to the individuals afflicted, including epilepsy, cerebral palsy,
and cognitive impairment.
At present, treatment is focused on managing the symptoms of perinatal asphyxia.
As new treatments are clearly needed, various models have been developed to test
We discuss the strength and limitations of each of the most commonly used animal
We finish with a discussion existing treatments for acute care, including
hypothermia, and the most promising pharmacological candidates for clinical use.