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Carnosine and Oxidative Stress in Cells and Tissues
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Authors: Alexander A. Boldyrev (M.V. Lomonosov Moscow State Univ., Russia) 
Book Description:
The main aim of this new book is to summarize the knowledge on the metabolic transformation of carnosine in excitable tissues of animals and human beings and to analyze the nature of its biological activity. At the beginning of monograph, the short history of the problem is stated. Distribution of carnosine in tissues, its appearance in ontogeny of vertebrates and correlation between carnosine content and functional activity of tissues are discussed. Chemical properties of carnosine and its natural derivatives and their ability to bind heavy metals and protons in water solution are documented. Special attention is paid to free radical quenching ability and to anti-glycating action. Biological activity of carnosine and carnosine containing compounds was tested using biological models of several levels of complexity, starting from individual enzymes and acellular mixtures and finishing to living cells and survival animals. Effects of carnosine on the whole animals under ischemic, hypoxic and other extreme conditions are described. In conclusion, the ability of carnosine to protect brain and muscular tissues from oxidative injury during exhausting exercise, extreme loading or neurodegenerative diseases is demonstrated. Based on these properties, carnosine is postulated to be a potent protector of human beings from oxidative stress.

Table of Contents:
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Preface;

Dedication

Chapter I.- Part I. Carnosine and Related Compounds: The History of the Problem; pp. 1-35

Chapter II.- Part II. Histidine-Containing Dipeptides and Functions of Excitable Tissues; pp. 37-100

Chapter III.- Part III. Oxidative Stress in Excitable Tissues;
pp. 101-128

Chapter IV.- Part IV. Histidine-Containing Dipeptides as Hydrophilic Tissue Antioxidants; pp. 129-165

Chapter V.- Part V. Effects of Histidine-Containing Dipeptides under Conditions of Disturbed Blood Circulation in Heart and Brain;
pp. 165-203

Chapter VI.- Part VI.Prospects of Pharmacological Applications of Carnosine; pp. 205-223

Chapter 7.- Histidine-Containing Dipeptides as Regulators of Cellular Homeostasis (Conclusion); 225-227

Chapter 8.- Protection of Proteins from Oxidative Stress - A New Illusion or a Novel Strategy (Addendum); pp. 229-235

Concluding Remarks
Acknowledgements
References

Index

   Binding: Hardcover
   Pub. Date: 2006
   ISBN: 1-60021-411-8
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Carnosine and Oxidative Stress in Cells and Tissues