Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Endocrinology » Gonadotropin-Releasing Hormone (GnRH): Production, Structure and Functions Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Psychology of Loneliness: New Research
$73.80
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to GnRH-Based Drug Targeting: Cell Adhesion and Migration Modulator Effects of GnRH Derivatives in Tumor Cells => pp. 254-272
Tell A Friend
 
Tell someone you know about this product.
GnRH-Based Drug Targeting: Cell Adhesion and Migration Modulator Effects of GnRH Derivatives in Tumor Cells => pp. 254-272 $100.00
Authors:  (László Kőhidai, Eszter Lajkó and Lívia Polgár, Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary, Ildikó Szabó and Gábor Mező, Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University; Budapest Hungary and Marilena Manea, Department of Chemistry and Zukunftskolleg, University of Konstanz; Konstanz Germany)
Abstract:
The decapeptide gonadotropin-releasing hormone (GnRH) is responsible for the regulation of reproductive function in the pituitary. Several natural isoforms (GnRH-I, GnRH-II, GnRH-III) and synthetic GnRH analogues, both agonists and antagonist, have been proven to exert antiproliferative effects mediated by GnRH receptors (GnRH-Rs) that are overexpressed in cancer cells compared to their expression in normal peripheral tissues. The application of cytotoxic drugs covalently linked to a GnRH peptide represents a promising approach to deliver the drug selectively to tumors overexpressing GnRH-Rs and consequently to improve the efficacy of tumor therapy. The targeted chemotherapy favors synthetic GnRH analogues such as GnRH-III and its derivatives (dimers and fragments), which directly inhibit the tumor growth without exerting significant endocrine side effects. The activity of cell physiological functions such as cell adhesion and chemotaxis (migration) basically determine the prognosis (dissemination) and the targeted treatment of cancer. The possible use of anticancer and antimetastatic GnRH-III peptides as drug delivery systems was investigated. The GnRH-III derivatives were applied as targeting moieties, while their drug (e.g., daunorubicin–Dau, doxorubicin–Dox) containing conjugates were tested by using adequate, cutting edge techniques of impedimetry acting on cell adhesion, chemotaxis/migration and proliferation in diverse model cells. Many types of cancer cells exhibit impaired adhesion and enhanced motility which allow the metastatic spreading. This prompted us to investigate the effects of GnRH-III derivatives and conjugates in tumor model cells such as Mono Mac 6 human leukemia cell line. The adhesion inducer effect of GnRH-III peptides with targeting potency is a rather general character in the leukemia model cell, while the chemotactic effects of the monomers containing a branch on Lys8 of GnRH-III proved to be dependent on the length of the branch. In case of conjugates the application of the doxorubicin as a drug (GnRH-III(Dox-ester)) or dimerization of the conjugates
([GnRH-III(Dau-oxime-C)]2) could significantly increase the adhesion inducer and chemorepellent character, activities which are favorable for drug targeting conjugates to inhibit the invasion of tumor cells. The majority of the conjugates (e.g., GnRH-III(Doxester)) could inhibit the growth of different types of tumor cells (leukemia–Mono Mac 6, human breast cancer–MCF-7, human colon cancer–HT-29). In addition to the notable antitumor activity of the GnRH-III based conjugates, the combined adhesion inducer and chemorepellent effects of both targeting units and their conjugates suggested their possible inhibitory action on invasion of a primary tumor and potential use in targeted tumor therapy. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Global Political Economy after the Crisis: Theoretical Perspectives and Country Experiences
02.Palliative Care: Perspectives, Practices and Impact on Quality of Life. A Global View, Volume 1
03.Trace Metals: Evolution, Environmental and Ecological Significance
04.Informal Learning: Perspectives, Challenges and Opportunities
05.Dissolved Organic Matter (DOM): Properties, Applications and Behavior
06.Green Polymeric Materials: Advances and Sustainable Development
07.Readings in the 20th Century Genocide of the Syriac Orthodox Church of Antioch (Sayfo)
08.Human Collaboration in Homeland Security (DVD Included)
09.Health and Freedom in the Balance: Exploring the Tensions among Public Health, Individual Liberty, and Governmental Authority
10.Innovations in Dialysis Vascular Access Surgery
11.Major Depressive Disorder: Risk Factors, Characteristics and Treatment Options
12.Inulin: Chemical Properties, Uses and Health Benefits

Nova Science Publishers
© Copyright 2004 - 2017

GnRH-Based Drug Targeting: Cell Adhesion and Migration Modulator Effects of GnRH Derivatives in Tumor Cells => pp. 254-272