Systems Biology and Environmental Exposures (pp. 81-130)
Authors: (Julia E. Rager and Rebecca C. Fry, Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA, and others)
Abstract: Mounting evidence shows that the altered signaling of critical cellular pathways
plays a major role in environmental toxicant exposure-induced disease. The current
understanding of systems level perturbations caused by exposure to environmental
toxicants continues to grow. Here we summarize the literature relating pathway responses
to six important toxicants, namely arsenic, benzene, cadmium, chromium, cigarette
smoke, and formaldehyde. By integrating the data presented in the current review, we
identify the “Environmental Toxicant Signalisome”, a network containing pathways that
are commonly responsive to varied environmental exposures in mammals. This chapter
provides an overview of signaling pathways that are known to be modulated by
environmental toxicants of relevance to human exposure and disease.
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