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The In-Vitro Response of Human Peripheral Blood Neutrophils to Fusobacterium nucleatum (pp. 59-66) $0.00
Authors:  Vivian Y. Wahaidi, George J. Eckert, Richard L. Gregory, Michael J. Kowolik, and Dominique M. Galli
Abstract:
Fusobacterium nucleatum is associated with periodontal disease and bacteremias of
oral origin. The interaction between oral bacteria and host defense is central in linking
oral and systemic diseases.
Purpose: To evaluate the oxidative response of human peripheral blood neutrophils,
in terms of priming and activation, to F. nucleatum.
Methods: The oxidative activity of peripheral blood neutrophils was evaluated by
luminol-enhanced chemiluminescence. Assays were conducted using F. nucleatum
ATCC 10953. In addition, Staphylococcus aureus ATCC 9144 and Aggregatibacter
actinomycetemcomitans ATCC 33384 were used as bacterial controls. All bacteria were
killed by exposure to UV light prior to use in the assays. Comparisons among the groups
were performed using ANOVA.
Results: Activation of neutrophils with F. nucleatum resulted in significantly higher
total chemiluminescence (p<0.05) when compared to A. actinomycetemcomitans and S.
aureus. Priming of neutrophils with N-formyl-L-methionyl-L-leucyl-L-phenylalanine or
F. nucleatum did not increase the chemiluminescence response.
Clinical Significance: Despite the absence of a priming effect, the current study
confirmed that F. nucleatum is a potent activator of peripheral blood neutrophils, thus
increasing systemic levels of oxidative stress and risk for systemic disease. 


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The In-Vitro Response of Human Peripheral Blood Neutrophils to Fusobacterium nucleatum (pp. 59-66)