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Melatonin: From Molecules to Therapy
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Editors: S. R. Pandi-Perumal (Mount Sinai School of Medicine, New York, USA) and Daniel P. Cardinali (University of Buenos Aires, Argentina)
Book Description:
Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This new and important book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.

Table of Contents:
Preface;

Section I. Molecular Perspectives

Chapter I - Chromatographic Analyses of Biogenic Melatonin and Its Related Indoleamines; pp. 3-21
(T. Harumi, S. R. Pandi-Perumal., G. R. Martinez., P. Di Mascio and Y. Hayashi);

Chapter II - 5-Methoxylated Kynuramines - Biologically Active Melatonin Metabolites and Sources of New Products; pp. 23-32
(Rüdiger Hardeland);

Chapter III - Advances on the Development of Subtype Selective Melatonin Ligands; pp. 33-45
(Gilberto Spadoni and Annalida Bedini);

Chapter IV - The interaction between melatonin and calmodulin: a NMR and molecular dynamics study; pp. 47-68
(Adrian G. Turjanski, Dario A. Estrin, Ruth E. Rosenstein, John E. McCormick, Stephen R. Martin, Annalisa Pastore, Rodolfo R. Biekofsky and Vincenzo Martorana)

Chapter V - The low affinity binding of melatonin to calmodulin: use of computational methods to explain its physiological relevance;
pp. 69-79
(Landau Meytal and Zisapel Nava);

Chapter VI - Neural regulation of melatonin synthesis; pp. 81-115
(Piyarat Govitrapong, Banthit Chetsawanga, Sujira Mukdaa and Pansiri Phansuwan-Pujitoc);

Chapter VII - Regulation of melatonin Synthesis: Animal versus Human Studies; pp. 117-134
(B. B. P. Gupta, and R. Spessert);

Chapter VIII - Toward a chronome (time structure) of melatonin;
pp. 135-176
(Germaine Cornélissen, Franz Halberg, Michal Zeman, Rita Józsa, Roberto Tarquini, Federico Perfetto, Roberto Salti and Earl E Bakken);

Chapter IX - Chronobiological aspects of melatonin activity;
pp. 177-195
(Diego A. Golombek and Gastón A. Pizzio);

Chapter X - The molecular basis to the circadian effects of melatonin; pp. 197-206
(DG Hazlerigg, 2JD Johnston, 1 J-M Fustin);

Chapter XI - Melatonin effects on uterine physiology; pp. 207-217
(James Olcese);

Chapter XII - Melatonin and Human Reproduction: Why the effect is so elusive?; pp. 219-225
(Amnon Brzezinski);

Chapter XIII - Melatonin: Immunomodulatory Signal; pp. 227-245
(Andrew K. Hotchkiss and Randy J. Nelson);

Chapter XIV - Photoperiodic vs. non-photoperiodic animals – circadian and seasonal changes in immunity; pp. 247-260
(Krystyna Skwarlo-Sonta, Pawel Majewski, Joanna Pawlak and Magdalena Markowska);

Chapter XV - Melatonin: an endogenous antiestrogen with oncostatic properties; pp. 261-272
(E. J. Sánchez-Barceló, S. Cos. Mediavilla, C. M. Martínez-Campa, A. González, C. Alonso-González and S. Sánchez-Mateos);

Chapter XVI - Melatonin and Cancer: Basic Research; pp. 273-282
(Marek Pawlikowski and Katarzyna Winczyk);

Chapter XVII - Melatonin in retinal pathophysiology; pp. 283-294
(Ruth E. Rosenstein);

Chapter XVIII - The physiology, pharmacology, and anatomical distribution of melatonin receptors in visual system nuclei in the vertebrate CNS; pp. 295-315
(Susan B. Udin and Irina V. Zhdanova);

Chapter IXX - Antioxidant capacity of the neurohormone melatonin; pp. 317-326
(E. Sofic and I. Tahirovic);

Chapter XX - Protective role of melatonin against mitochondrial damage in inflammation; pp. 327-347
(D. Acuña-Castroviejo, G. Escames, L. C. López, A. B. Hitos and L. León);

Chapter XXI - Protective effects of melatonin against hyperhomocysteinemia; pp. 349-368
(Giyasettin Baydas);

Chapter XXII - Photo- and radiation induced reactions of melatonin by laser photolysis and pulse radioloysis; pp. 369-385
(Mingzhang Lin, Hui He and Yosuke Katsumura);

Chapter XXIII - Melatonin action on neuropeptide induction through receptor-mediated mechanisms in the brain; pp. 387-400
(Kazuyoshi Tsutsui, Takayoshi Ubuka1 and George E. Bentley);

Chapter XXIV - Melatonin Receptors in Neuroendocrine Development; pp. 401-411
(J. D. Johnston, D. G. Hazlerigg and G. Wagner);

Chapter XXV - The effects of exogenous melatonin on the morphology of thyrocytes in pinealectomized and irradiated rats; pp. 413-424
(Z. Kundurovic and E. Sofic);

Chapter XXVI - The control of Melatonin release from mammalian and avian pineal glands; pp. 425-455
(Valér Csernus, András D. Nagy, Nándor Faluhelyi);

Chapter XXVII - Effects of chronic melatonin administration on various physiological parameters from old wistar rats; pp. 457-480
(Jesus A. F. Tresguerres, Carmen Castillo, Veronica Salazar, Ana F. Tresguerres, Elena Vara, Iñigo Azcoitia, Mónica de la Fuente and Carmen Ariznavarreta);

Section II. Therapeutic Perspectives

Chapter XXVIII - Pineal region tumors; pp. 483-497
(Michal Karasek, Marek Mandera and Wielislaw Papierz);

Chapter XXIX - Melatonin and Cancer: therapeutic perspectives;
pp. 499-528
(Eva S. Schernhammer);

Chapter XXX - Therapeutic perspectives of gastrointestinal melatonin; pp. 529-545
(George A. Bubenik);

Chapter XXXI - Endogenous Versus Exogenous Effects of Melatonin;
pp. 547-569
(Kenneth P. Wright Jr. and Naomi L. Rogers);

Chapter XXXII - Melatonin Circadian Rhythms in Women with Depression: Relationship to the Reproductive Cycle; pp. 571-580
(Barbara L. Parry, Charles J. Meliska, L. Fernando Martínez, Ana M. López, Diane L. Sorenson, Sara Nowakowski and Richard T. Loving);

Chapter XXXIII - Melatonin therapy of circadian rhythm sleep disorders in neurodevelopmentally disordered children: a neurological viewpoint; pp. 581-604
(James E. Jan, Michael B. Wasdell, Melissa Bomben, Roger D. Freeman and Wop J. Rietveld);

Chapter XXXIV - Treatment by melatonin of a genetic disorder: Smith-Magenis syndrome; pp. 605-613
(Hélène De Leersnyder);

Chapter XXXV - Melatonin and sleep in shift-workers; pp. 615-632
(V. Srinivasan, S. R. Pandi-Perumal, W. Spence., L. Kayumov and D. P. Cardinali);

Chapter XXXVI - Role of Melatonin in the regulation of human circadian rhythms and sleep; pp. 633-645
(Christian Cajochen, Kurt Kräuchi, Anna Wirz-Justice);

Chapter XXXVII - Ramelteon, a selective MT1/MT2 receptor agonist, provides a novel treatment for insomnia; pp. 647-667
(Masaomi Miyamoto);

Chapter XXXVIII - Melatonin, Dopamine and Circadian Rhythm in the Restless Legs Syndrome; pp. 669-680
(Stephany Fulda and Thomas C. Wetter);

Chapter XXXIX - Sleep and Circadian Neuroendocrine Dysregulation in Seasonal Affective Disorder; pp. 681-697
(S. R. Pandi-Perumal, W. Spence, A. D. Lowe, L. Kayumov, D. P. Cardinali, T. Partonen and A. A. Putilov );

Chapter XL - Involvement of free radicals and reactive oxygen species in physiological and pathological processes in the thyroid gland; a potential role of melatonin; pp. 699-716
(Andrzej Lewinski and Malgorzata Karbownik);

Chapter XLI - Role of melatonin in Headache disorders; pp. 717-729
(Mario Fernando Prieto Peres);

Chapter XLII - Ambient illumination and melatonin in the natural setting; pp. 731-752
(Jean-Louis Girardin);

Chapter XLIII - Melatonin: effects on smooth muscle and clinical utility; pp. 753-758
(Mustafa Sajeel and Marcus Drake);

Chapter XLIV - Melatonin and woman; pp. 759-770
(Betul Ugur-Altun and Armagan Altun);

Chapter XLV - Effects of Melatonin on Cardiovascular System;
pp. 771-784
(Armagan Altun and Betul Ugur-Altun);

Chapter XLVI - Melatonin and cerebrovascular disease; pp. 785-801
(Raymond Tak Fai Cheung);

Chapter XLVII - Melatonin in Focal Cerebral Ischaemia - Evidence for efficacy and priorities for future research; pp. 803-812
(Malcolm Macleod);

Chapter XLVIII - Understanding the role of melatonin in epilepsy: from bench to bedside; pp. 813-825
(Madhur Gupta, 1Lee S. Stewart and Y. K. Gupta);

Chapter XLIX - Role of Melatonin on Alzheimer’s disease; pp. 827-840
(Ze-Feng Wang and Jian-Zhi Wang);

Chapter L - Longitudinal measurements of melatonin secretion in the elderly: Implications for Alzheimer’s Disease; pp. 841-848
(N. M. K. Ng Ying Kin, N. P. V. Nair, G. Schwartz and J. X. Thavundayil);

Chapter LI - Interactions of Melatonin With Environmental Factors; pp. 849-861
(Masami Ishido, National Institute for Environmental Studies, Japan)

Author Index;
Subject Index.

   Binding: Hardcover
   Pub. Date: 2007
   ISBN: 1-60021-121-6
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Melatonin: From Molecules to Therapy