Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Genetics » New Research on DNA Damage Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Executive Departments of the US Government: Current Issues and Challenges
$85.50
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to The Induction and Repair of DNA-Protein Crosslinks in Mammalian Cells (pp. 347-378)
Tell A Friend
 
Tell someone you know about this product.
The Induction and Repair of DNA-Protein Crosslinks in Mammalian Cells (pp. 347-378) $100.00
Authors:  (Sharon Barker, Michael Weinfeld and David Murray, Department of Oncology, Division of Experimental Oncology, University of Alberta, Edmonton, Alberta, Canada)
Abstract:
DNA-protein crosslinks (DPCs), which are generated by covalent linkage of proteins
to the DNA duplex, comprise an under-studied class of DNA lesions. They can be
induced by commonly encountered agents including environmental chemicals, cancerchemotherapeutic
drugs and ionizing radiation. DPCs could pose a serious threat to
cellular function because they may disrupt the progression of the replication and
transcription machineries. A number of problems have plagued researchers examining
this type of DNA damage. Many agents can induce DPCs by more than one chemical
mechanism. Furthermore, these agents invariably induce other types of DNA damage.
Measurements of DPC damage have also been hampered by the lack of stringent and
sensitive methodologies for their isolation. However, recent advances in DPC-isolation
methodology have allowed for more in-depth analyses of these lesions. Additionally,
advances in the study of chromatin structure have provided further understanding of the
influence of chromatin dynamics on the induction and repair of DPCs. At the same time,
our improving knowledge of many DNA-repair pathways has afforded opportunities for
assessing the involvement of these pathways in the removal of DPCs from the genome.
This chapter will discuss the impact of these advances on our understanding of DPCs and
their biological consequences. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Flavonoids in the Fight against Upper Gastrointestinal Tract Cancers
02.Resilience and Health: A Potent Dynamic
03.Alpha Lipoic Acid: New Perspectives and Clinical Use in Obstetrics and Gynecology
04.Advances in Psychobiology
05.Biodiversity in Time and Space
06.Multifaceted Autoethnography: Theoretical Advancements, Practical Considerations and Field Illustrations
07.Islam and Muslims in Europe
08.Violence Against Women in the 21st Century: Challenges and Future Directions
09.Challenges and Opportunities for Eurozone Governance
10.Flour: Production, Varieties and Nutrition
11.Liquid Metals: From Atomistic Potentials to Properties, Shock Compression, Earth's Core and Nanoclusters
12.Polyunsaturated Fatty Acids (PUFAs): Food Sources, Health Effects and Significance in Biochemistry

Nova Science Publishers
© Copyright 2004 - 2018

The Induction and Repair of DNA-Protein Crosslinks in Mammalian Cells (pp. 347-378)