Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Genetics » New Research on DNA Damage Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Temporal Lobe Epilepsy: Pathologic Substrates and Causes
$82.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Mutational Hotspots of TP53 Gene Associated to DNA Damage (pp. 319-342)
Tell A Friend
 
Tell someone you know about this product.
Mutational Hotspots of TP53 Gene Associated to DNA Damage (pp. 319-342) $100.00
Authors:  (Angélica Rangel-Lopez, José Ramon Pniagua-Sierra, Unidad de Investigacion Medica en Enfermedades Nefrolňgicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Mexico)
Abstract:
TP53 is the most commonly mutated gene in human cancers, and the p53 protein is a
potent inhibitor of cell growth, arresting cell cycle progression at several points and
inducing apoptosis of cells undergoing uncontrolled growth. The loss of p53 function by
mutation is too common in cancer. However, most natural p53 mutations occur at a late
stage in tumor development, and many clinically detectable cancers have reduced p53
expression but no p53 mutations.
Approximately 90% of the TP53 gene mutations are localized between domains
encoding exons 5 to 8. Much research suggests that TP53 mutations have prognostic
importance and sometimes are a significant factor in clinical Oncology. The presence of
specific p53 mutational hotspots in different types of cancer implicates environmental
carcinogens and endogenous processes in the etiology of human cancer. Oxidative stress
and the generation of reactive species may cause mutations in cancer-related genes, and
affect key regulator proteins of DNA repair, cell cycle, and apoptosis.
This review gives a brief perspective of some of the landmark discoveries in
mutation research. The molecular and biochemical characteristics of TP53 and p53 are
then covered, followed by an overview of how it can be studied in the laboratory.
Finally, the implications of mutational hotspots of TP53 gene at the level of DNA
damage are discussed. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Peter Singer’s Ethics: A Critical Appraisal
02.Sexism: Past, Present and Future Perspectives
03.Body and Politics: Elite Disability Sport in China
04.Childhood and Adolescence: Tribute to Emanuel Chigier, 1928-2017
05.Renal Replacement Therapy: Controversies and Future Trends
06.Food-Drug Interactions: Pharmacokinetics, Prevention and Potential Side Effects
07.Terrorism and Violence in Islamic History and Theological Responses to the Arguments of Terrorists
08.International Event Management: Bridging the Gap between Theory and Practice
09.The Sino-Indian Border War and the Foreign Policies of China and India (1950-1965)
10.Tsunamis: Detection, Risk Assessment and Crisis Management
11.Sediment Watch: Monitoring, Ecological Risk Assessment and Environmental Management
12.Self-Regulated Learners: Strategies, Performance, and Individual Differences

Nova Science Publishers
© Copyright 2004 - 2018

Mutational Hotspots of TP53 Gene Associated to DNA Damage (pp. 319-342)