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DNA Damage through Photo-Induced Electron Transfer and Photosensitized Generation of Reactive Oxygen Species (pp. 197-219) $100.00
Authors:  (Kazutaka Hirakawa, Department of Basic Engineering, Faculty of Engineering, Shizuoka University, Japan)
Abstract:
DNA damage via photosensitized reaction such as photo-induced electron transfer
and photosensitized reactive oxygen formation contributes to solar carcinogenesis and
phototoxic effect. Furthermore, DNA damage by photosensitized reaction is important
mechanism of photodynamic therapy, which is a promising treatment of cancer and other
non-malignant conditions. The mechanism of photosensitized DNA damage strongly
depends on the excitation energy of photosensitizer, i.e. the wavelength is important. In
general, ultra-violet photosensitizer induces DNA damage via the electron transfer,
whereas photosensitized singlet oxygen generation is important for the mechanism by
visible-light photosensitizer. Guanine residue is the important target of the two
mechanisms, electron transfer and singlet oxygen generation. The consecutive guanines
are selectively oxidized through electron transfer, because these sites act as hole-trap.
Singlet oxygen induces base oxidation at every guanine residues. Rarely, superoxide
anion radical, which is formed through photo-induced electron transfer from excited
photosensitizer to molecular oxygen, contributes to DNA damage. Superoxide itself
hardly damages DNA, but hydrogen peroxide and hydroxyl radical formed from
superoxide are important reactive species for DNA damage. 


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DNA Damage through Photo-Induced Electron Transfer and Photosensitized Generation of Reactive Oxygen Species (pp. 197-219)