Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Genetics » New Research on DNA Damage Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Civil Liberties: Overview, Issues and Trends
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Polymorphisms in Genes Involved in DNA-Damage Processing and Their Effect on Cancer Risk (pp. 113-124)
Tell A Friend
Tell someone you know about this product.
Polymorphisms in Genes Involved in DNA-Damage Processing and Their Effect on Cancer Risk (pp. 113-124) $100.00
Authors:  (G. Iarmarcovai, A. Botta, T. Orsière, Laboratory of Biogenotoxicology and Environmental Mutagenesis, Faculty of Medecine, Université de la Méditerranée, France, S. Bonassi, Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy, R.A. Baan, Carcinogen Identification and Evaluation Group, WHO - International Agency for Research on Cancer, France)
The individual response to genotoxic stress and induction of DNA damage may vary
according to various conditions, such as the absorption and metabolism rate of genotoxic
agents, the extent and efficacy of DNA-damage induction and repair, the balance
between apoptosis and necrosis of exposed cells, the proper functioning of cell-cycle
control, and the immune response. All of these processes are governed by certain genes
or combinations of genes. Numerous human population studies have evaluated the
relationship between genetic polymorphisms and DNA-damage induction and repair in
response to genotoxic insult. The most common type of variation in DNA sequence is the
single-nucleotide polymorphism, present in about 1 per 1,000 nucleotides in the human
genome. However, the role of this type of genetic variant contributing to diseases with a
complex etiology such as cancer is poorly understood. Hundreds of polymorphisms in
genes that encode enzymes involved in the metabolism of xenobiotics (such as
oxidoreductases, P450 cytochromes, glutathione S-transferases, N-acetyl transferases,
methyltransferases, hydrolases, dehydrogenases), in DNA repair (participating in direct
reversal repair, base-excision repair, nucleotide-excision repair, and double-strand-break
repair), and in folate metabolism (methylenetetrahydrofolate reductase, methionine
synthase, methionine synthase reductase) have been identified, although for many of
these polymorphisms the impact on repair phenotype and cancer susceptibility remains
uncertain. The present article reviews which of the many single-nucleotide
polymorphisms in genes involved in DNA-damage processing influence cancer risk, and
provides insight into the complexity of the genotype-phenotype relationship.
Nevertheless, when a specific polymorphism by itself appears to have no or only a weak
effect, the identification and characterization of the combined effects of different
susceptibility genes for cancer risk require the understanding of gene-gene interactions. 

Available Options:
This Item Is Currently Unavailable.
Special Focus Titles
01.Flavonoids in the Fight against Upper Gastrointestinal Tract Cancers
02.Resilience and Health: A Potent Dynamic
03.Alpha Lipoic Acid: New Perspectives and Clinical Use in Obstetrics and Gynecology
04.Advances in Psychobiology
05.Biodiversity in Time and Space
06.Multifaceted Autoethnography: Theoretical Advancements, Practical Considerations and Field Illustrations
07.Islam and Muslims in Europe
08.Violence Against Women in the 21st Century: Challenges and Future Directions
09.Challenges and Opportunities for Eurozone Governance
10.Flour: Production, Varieties and Nutrition
11.Liquid Metals: From Atomistic Potentials to Properties, Shock Compression, Earth's Core and Nanoclusters
12.Polyunsaturated Fatty Acids (PUFAs): Food Sources, Health Effects and Significance in Biochemistry

Nova Science Publishers
© Copyright 2004 - 2018

Polymorphisms in Genes Involved in DNA-Damage Processing and Their Effect on Cancer Risk (pp. 113-124)