Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Genetics » New Research on DNA Damage Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Recycled Cooking Oil: Processing and Uses
$82.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Radiation-Induced DNA Damage Responses as Novel Targets in Cancer Treatments (pp. 61-97)
Tell A Friend
 
Tell someone you know about this product.
Radiation-Induced DNA Damage Responses as Novel Targets in Cancer Treatments (pp. 61-97) $100.00
Authors:  (Wei-Dong Wang, Zheng-tang Chen, Department of Radiation Oncology, Cancer Institute of PLA, Xinqiao Hospital, Rong Li,Institute of Combined Injuries, College of Preventive Medicine, Third Military Medical University, China)
Abstract:
The amazing feature of ionizing radiation (IR) as a DNA damaging agent is the
range of lesions it induces. Such lesions include base damage, single strand breaks
(SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A
range of DNA damage response mechanisms operate to help maintain genomic stability
in the face of such damage. Such mechanisms include pathways of DNA repair and
signal transduction mechanisms. Increasing evidence suggests that these pathways
operate co-operatively. In addition, the relative impact of one mechanism over another
most probably depends upon the cell cycle phase and tissue type. An increased DNArepair
activity in tumor cells has been associated with resistance to treatment to DNAdirected
drugs, while defects in DNA repair pathways result in hypersensitivity to these
agents. In the past years the unraveling of the molecular basis of these DNA pathways,
with a better understanding of the DNA damage caused by different anticancer agents,
has provided the rationale for the use of some DNA repair inhibitors to optimize the
therapeutic use of DNA-damaging agents currently used in the treatment of tumors. In
addition, the possibility to specifically target the differences in DNA repair capacity
between normal and tumor cells has recently emerged as an exciting possibility. We
anticipate that this approach cannot be pursued in all cancer patients and using the same
regimes, but it should be tailored according to the specific tumor DNA repair pattern.
Therefore, as already clearly demonstrated for other target therapies, it seems essential to
develop reliable markers and imaging techniques to be used for an appropriate patientís
selection and as predictors of response. This review will focus on the new therapeutic
strategies for DNA damage repair inhibition and their application in anticancer therapy. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Multicultural and Citizenship Awareness through Language: Cross Thematic Practices in Language Pedagogy
02.The Brainstem and Behavior
03.Sustainable Development: The Context of Use of Indigenous Plants for Local Economic Growth
04.Cancer versus Nutraceuticals
05.Fundamentals of Fuel Injection and Emission in Two-Stroke Engines
06.Free to Love: Schema Therapy for Christians
07.Textiles: Advances in Research and Applications
08.Cheese Production, Consumption and Health Benefits
09.Education in Lesotho: Prospects and Challenges
10.Work-Life Balance in the 21st Century: Perspectives, Practices, and Challenges
11.Electrical Measurements: Introduction, Concepts and Applications
12.Potassium Channels in Health and Disease

Nova Science Publishers
© Copyright 2004 - 2018

Radiation-Induced DNA Damage Responses as Novel Targets in Cancer Treatments (pp. 61-97)