Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Genetics » New Research on DNA Damage Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Advances in Materials Science Research. Volume 32
$225.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to DNA Adductomics: Global Assessment of DNA Damage (pp. 49-60)
Tell A Friend
 
Tell someone you know about this product.
DNA Adductomics: Global Assessment of DNA Damage (pp. 49-60) $100.00
Authors:  (Robert A. Kanaly, Laboratories of Environmental Microbiology and Molecular Toxicology, Dept. of Environmental Biosciences, Yokohama City Univ., Yokohama, Japan, Tomonari Matsuda, Dept. of Technology and Ecology, Graduate School of Global Environmental Studies, Kyoto Univ., Kyoto, Japan)
Abstract:
DNA adductomics is the systematic analysis of large numbers of DNA adducts or
DNA modifications present in a particular DNA sample obtained at a specific point in
time. The resulting DNA adductomes are represented visually by “DNA adduct
fingerprint” adductome maps and adductome profiles that are unique to each DNA
sample. In combination, the map and profile interfaces serve to provide detailed
visualizations of DNA modification occurrence patterns and allow for comparisons
between multiple samples. Additionally, the identities of specific DNA modifications
revealed by the maps may be determined, e.g. DNA damage in the form of a DNA
adduct. The DNA adductome approach utilizes liquid chromatography coupled with
electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) and the
methodology is designed to detect the neutral loss of 2’-deoxyribose from positively
ionized 2’-deoxynucleoside adducts in multiple reaction monitoring mode (MRM)
transmitting the [M+H]+ > [M+H-116]+ transition over multiple transitions. Data analysis
is optimized and coupled with a comprehensive manual screening process designed to
minimize the number of artifactual DNA modifications that appear in the final analyses.
Identification of DNA adducts is carried out by comparison to authentic standards and by
stable isotope dilution methods. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Multicultural and Citizenship Awareness through Language: Cross Thematic Practices in Language Pedagogy
02.The Brainstem and Behavior
03.Sustainable Development: The Context of Use of Indigenous Plants for Local Economic Growth
04.Cancer versus Nutraceuticals
05.Fundamentals of Fuel Injection and Emission in Two-Stroke Engines
06.Free to Love: Schema Therapy for Christians
07.Textiles: Advances in Research and Applications
08.Cheese Production, Consumption and Health Benefits
09.Education in Lesotho: Prospects and Challenges
10.Work-Life Balance in the 21st Century: Perspectives, Practices, and Challenges
11.Electrical Measurements: Introduction, Concepts and Applications
12.Potassium Channels in Health and Disease

Nova Science Publishers
© Copyright 2004 - 2018

DNA Adductomics: Global Assessment of DNA Damage (pp. 49-60)