Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Genetics » New Research on DNA Damage Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Introduction to the Three-Plane Corpuscular-Wave Biology of Forest Tree Species
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to DNA Adductomics: Global Assessment of DNA Damage (pp. 49-60)
Tell A Friend
Tell someone you know about this product.
DNA Adductomics: Global Assessment of DNA Damage (pp. 49-60) $100.00
Authors:  (Robert A. Kanaly, Laboratories of Environmental Microbiology and Molecular Toxicology, Dept. of Environmental Biosciences, Yokohama City Univ., Yokohama, Japan, Tomonari Matsuda, Dept. of Technology and Ecology, Graduate School of Global Environmental Studies, Kyoto Univ., Kyoto, Japan)
DNA adductomics is the systematic analysis of large numbers of DNA adducts or
DNA modifications present in a particular DNA sample obtained at a specific point in
time. The resulting DNA adductomes are represented visually by “DNA adduct
fingerprint” adductome maps and adductome profiles that are unique to each DNA
sample. In combination, the map and profile interfaces serve to provide detailed
visualizations of DNA modification occurrence patterns and allow for comparisons
between multiple samples. Additionally, the identities of specific DNA modifications
revealed by the maps may be determined, e.g. DNA damage in the form of a DNA
adduct. The DNA adductome approach utilizes liquid chromatography coupled with
electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) and the
methodology is designed to detect the neutral loss of 2’-deoxyribose from positively
ionized 2’-deoxynucleoside adducts in multiple reaction monitoring mode (MRM)
transmitting the [M+H]+ > [M+H-116]+ transition over multiple transitions. Data analysis
is optimized and coupled with a comprehensive manual screening process designed to
minimize the number of artifactual DNA modifications that appear in the final analyses.
Identification of DNA adducts is carried out by comparison to authentic standards and by
stable isotope dilution methods. 

Available Options:
This Item Is Currently Unavailable.
Special Focus Titles
01.Peter Singer’s Ethics: A Critical Appraisal
02.Sexism: Past, Present and Future Perspectives
03.Body and Politics: Elite Disability Sport in China
04.Childhood and Adolescence: Tribute to Emanuel Chigier, 1928-2017
05.Renal Replacement Therapy: Controversies and Future Trends
06.Food-Drug Interactions: Pharmacokinetics, Prevention and Potential Side Effects
07.Terrorism and Violence in Islamic History and Theological Responses to the Arguments of Terrorists
08.International Event Management: Bridging the Gap between Theory and Practice
09.The Sino-Indian Border War and the Foreign Policies of China and India (1950-1965)
10.Tsunamis: Detection, Risk Assessment and Crisis Management
11.Sediment Watch: Monitoring, Ecological Risk Assessment and Environmental Management
12.Self-Regulated Learners: Strategies, Performance, and Individual Differences

Nova Science Publishers
© Copyright 2004 - 2018

DNA Adductomics: Global Assessment of DNA Damage (pp. 49-60)