Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Genetics » New Research on DNA Damage Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Online Learning: An Educational Development Perspective
$125.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Cancer and Aging as Consequences of Un-Repaired DNA Damage (pp. 1-47)
Tell A Friend
 
Tell someone you know about this product.
Cancer and Aging as Consequences of Un-Repaired DNA Damage (pp. 1-47) $0.00
Authors:  (Harris Bernstein, Departments of Cell Biology and Anatomy, Arizona Cancer Center, College of Medicine, University of Arizona, Claire M. Payne, Departments of Cell Biology and Anatomy, Internal Medicine, Arizona Cancer Center, College of Medicine, University of Arizona, Carol Bernstein, Departments of Cell Biology and Anatomy, Section of Hematology/Oncology, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona, USA)
Abstract:
Cancer and aging appear to be consequences of DNA damage, a pervasive,
fundamental problem for living organisms. Un-repaired DNA damages in dividing cells
can cause errors during DNA synthesis leading to mutation and ultimately to cancer.
Furthermore, un-repaired DNA damages, especially in non- or infrequently dividing
cells, can accumulate and cause progressive blockage of transcription, loss of gene
expression capability and ultimately aging at the cellular, tissue and organ level. With
respect to cancer, the likely sources of DNA damage causing the most frequent deadly
cancers are reviewed, and it is concluded that, in general, reactive oxygen species
reactions with DNA, and DNA-adduct forming molecule reactions, are the chief sources
of damage. Approximately 30 inherited genetic defects in humans have been identified
that cause reduced DNA repair. In general, these genetic defects are associated with
increased cancer risk, indicating that increased DNA damage is causally related to
cancer. Furthermore, evidence indicates that after formation of a mutation that provides a
growth or survival advantage to a cell, the succeeding steps of progression to cancer
likely involve natural selection and formation of a pre-malignant defective field of cells,
a “field defect”. With respect to aging, evidence is reviewed that DNA damages,
particularly oxidative DNA damages, accumulate with age in the brain (29 studies) and
muscle (18 studies), as well as in liver, kidney and hematopoietic stem cells. This
accumulation is associated with a decline in expression of genes associated with the
aging process. A calorie-restricted diet is known to increase lifespan in mammals and is
also associated with decreased oxidative DNA damage. Inherited syndromes such as
Werner syndrome, Hutchinson-Guilford progeria, and Cockayne syndrome are due to
reduced DNA repair capability and are also associated with early aging, indicating that
increased DNA damage is causally related to aging. The principal source of DNA
damages leading to normal aging appears to be reactive oxygen species produced as
byproducts of cellular respiration. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Mountains: Geology, Topography and Environmental Concerns
02.A Short History of the Georgian Church
03.Private Investigations: Suspicion of Financial Crime by White-Collar Criminals
04.Cellular and Molecular Mechanisms of Honey Wound Healing
05.Controversies in Preeclampsia
06.Bioengineering Nursing: New Horizons of Nursing Research
07.Innovation and Global Competition: The Case of Korea
08.Network-Based Continuing Medical Education: Social Media and Professional Development
09.Fractional Calculus in Analysis, Dynamics and Optimal Control
10.The Infinite History of NOW: A Timeless Background for Contemporary Physics
11.Borderline Personality Disorder: Understanding the Unconscious Function of Deliberate Self Harm and Managing the Transference Relationship
12.Energy and Environment Nowadays

Nova Science Publishers
© Copyright 2004 - 2014

Cancer and Aging as Consequences of Un-Repaired DNA Damage (pp. 1-47)