Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Proteins » Laminins: Structure, Biological Activity and Role in Disease Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Medicine Research Summaries. Volume 20
$243.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by N-Glycosylation (pp. 29-52)
Tell A Friend
 
Tell someone you know about this product.
Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by N-Glycosylation (pp. 29-52) $0.00
Authors:  (Yoshinobu Kariya, Yukiko Kariya, Jianguo Gu, Departments of Biochemistry and Diagnostic Pathology, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima, Japan, and others)
Abstract:
Laminin-332 (formerly known as laminin-5) is a major component of basement
membranes in the skin and other stratified squamous epithelial tissues. Laminin-332 has
attracted much attention from both physicians and researchers as a disease-related and
functional molecule. The study of human genetic disorders and a knockout mouse model
has provided the evidence that laminin-332 is indispensable for adhesive structures in the
skin. In wound healing and cancer invasion, overexpression of laminin-332 accelerates
cell migration by activating PI3K, PKC, and MAPK signaling pathways. These
functional activities of laminin-332 are through interactions with several cell surface
receptors including integrins 3 1 and 6 4, and syndecans. In addition, recent studies
revealed that posttranslational modifications, such as proteolytic processing and Nglycosylation,
of laminin-332 and of integrins 3 1 and 6 4 are important for the
laminin-332 activities. This review summarizes the molecular mechanisms and
significance of cellular adhesion and migration through laminin-332 as well as integrins
3 1 and 6 4. Understanding of these regulatory mechanisms could lead to
development of new molecular targeted therapies, particularly in oncology. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Positive Youth Development: Long Term Effects in a Chinese Program
02.Anticancer Therapies: Advances in Research and Applications
03.From Dreamers to Doers: The Art and Science of Educational Project Management
04.Delirium: Prevention, Symptoms and Treatment
05.Mindfulness: Past, Present and Future Perspectives
06.Classrooms. Volume 2: Academic Content and Behavior Strategy Instruction for Students With and Without Disabilities
07.Bicycles: Helmet Use of Adolescents at Independent Schools
08.Alzheimer’s Disease: Awareness among Young Adults
09.What Your Eyes Tell Your Brain about Art: Insights from Neuroaesthetics and Scanpath Eye Movements
10.Pain: Management, Issues and Controversies
11.Gifted Underachiever
12.Biological Conservation in the 21st Century: A Conservation Biology of Large Wildlife

Nova Science Publishers
© Copyright 2004 - 2017

Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by <i>N</i>-Glycosylation (pp. 29-52)