Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Proteins » Laminins: Structure, Biological Activity and Role in Disease Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Financial Crises and Programs: Developments, Analyses and Research
$82.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by N-Glycosylation (pp. 29-52)
Tell A Friend
 
Tell someone you know about this product.
Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by N-Glycosylation (pp. 29-52) $0.00
Authors:  (Yoshinobu Kariya, Yukiko Kariya, Jianguo Gu, Departments of Biochemistry and Diagnostic Pathology, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima, Japan, and others)
Abstract:
Laminin-332 (formerly known as laminin-5) is a major component of basement
membranes in the skin and other stratified squamous epithelial tissues. Laminin-332 has
attracted much attention from both physicians and researchers as a disease-related and
functional molecule. The study of human genetic disorders and a knockout mouse model
has provided the evidence that laminin-332 is indispensable for adhesive structures in the
skin. In wound healing and cancer invasion, overexpression of laminin-332 accelerates
cell migration by activating PI3K, PKC, and MAPK signaling pathways. These
functional activities of laminin-332 are through interactions with several cell surface
receptors including integrins 3 1 and 6 4, and syndecans. In addition, recent studies
revealed that posttranslational modifications, such as proteolytic processing and Nglycosylation,
of laminin-332 and of integrins 3 1 and 6 4 are important for the
laminin-332 activities. This review summarizes the molecular mechanisms and
significance of cellular adhesion and migration through laminin-332 as well as integrins
3 1 and 6 4. Understanding of these regulatory mechanisms could lead to
development of new molecular targeted therapies, particularly in oncology. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Flavonoids in the Fight against Upper Gastrointestinal Tract Cancers
02.Resilience and Health: A Potent Dynamic
03.Alpha Lipoic Acid: New Perspectives and Clinical Use in Obstetrics and Gynecology
04.Advances in Psychobiology
05.Biodiversity in Time and Space
06.Multifaceted Autoethnography: Theoretical Advancements, Practical Considerations and Field Illustrations
07.Islam and Muslims in Europe
08.Violence Against Women in the 21st Century: Challenges and Future Directions
09.Challenges and Opportunities for Eurozone Governance
10.Flour: Production, Varieties and Nutrition
11.Liquid Metals: From Atomistic Potentials to Properties, Shock Compression, Earth's Core and Nanoclusters
12.Polyunsaturated Fatty Acids (PUFAs): Food Sources, Health Effects and Significance in Biochemistry

Nova Science Publishers
© Copyright 2004 - 2018

Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by <i>N</i>-Glycosylation (pp. 29-52)