Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Mathematics and Statistics » Advances in Computational Modeling Research: Theory, Developments and Applications Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
New Developments in Surveillance Systems and National Security
$190.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Agent-Based Models in Cancer Prevention Research (pp. 105-116)
Tell A Friend
 
Tell someone you know about this product.
Agent-Based Models in Cancer Prevention Research (pp. 105-116) $0.00
Authors:  (John W. Pepper, Nadarajen A. Vydelingum, Barbara K. Dunn, Richard M. Fagerstrom, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA)
Abstract:
Agent-based models have proven very useful for studying complex dynamic
processes. As biomedical researchers have turned their attention to the most complex
diseases, they have made increasing use of agent-based models in various areas,
including cancer biology. Cancer is arguably the ultimate complex biological system. It
has recently become clear that much of its complexity arises through Darwinian
evolution, driven by uncontrolled natural selection among rapidly mutating somatic cells.
Here we review the application of agent-based models and simulations to five key
open questions in cancer prevention research. The five research questions we review as
case studies include: 1) What normally prevents somatic evolution from generating
cancer? 2) Why do benign growths often progress to malignant cancers? 3) What is the
chronological sequence of molecular events in cancer progression? 4) Are there reliable
molecular biomarkers for cancer?; and 5) Will evolved drug resistance stymie efforts at
long-term cancer chemoprevention?
We conclude that molecular analysis can be usefully augmented by using agentbased
models to generate plausible and productive hypotheses for empirical testing. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Biomarker Discovery and Biotherapeutics Applications of Photosynthetic Light-Harvesting and Bioluminescence Light-Emitting Chromophore-Protein Complexes in Stem Cell Biology and Regenerative Medicine.
02.Collective Memory: How Collective Representations about the Past are Created, Preserved and Reproduced
03.The Limits of Civilization
04.Mexico in Focus: Political, Environmental and Social Issues
05.Sustainable North African Society: Exploring Seeds and Resources for Innovation
06.Environment and Public Health: Environmental Health, Law and International Perspectives
07.Stevia rebaudiana: Chemical Composition, Uses and Health Promoting Aspects
08.Pediatric Renal Transplantation: Protocols and Controversies
09.Mediastinal Infections: Clinical Diagnosis, Surgical and Alternative Treatments
10.Beyond Diet and Depression, Volume 1: Basic Knowledge, Clinical Symptoms and Treatment of Depression
11.Successful Conservation Strategies for Sea Turtles: Achievements and Challenges
12.Effects and Expectations of Tilapia as a Resource
13.Hygienically Relevant Biofilms

Nova Science Publishers
© Copyright 2004 - 2015

Agent-Based Models in Cancer Prevention Research (pp. 105-116)