Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Mathematics and Statistics » Advances in Computational Modeling Research: Theory, Developments and Applications Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Evidence Based Treatments for Eating Disorders: Children, Adolescents and Adults
$110.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Agent-Based Models in Cancer Prevention Research (pp. 105-116)
Tell A Friend
 
Tell someone you know about this product.
Agent-Based Models in Cancer Prevention Research (pp. 105-116) $0.00
Authors:  (John W. Pepper, Nadarajen A. Vydelingum, Barbara K. Dunn, Richard M. Fagerstrom, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA)
Abstract:
Agent-based models have proven very useful for studying complex dynamic
processes. As biomedical researchers have turned their attention to the most complex
diseases, they have made increasing use of agent-based models in various areas,
including cancer biology. Cancer is arguably the ultimate complex biological system. It
has recently become clear that much of its complexity arises through Darwinian
evolution, driven by uncontrolled natural selection among rapidly mutating somatic cells.
Here we review the application of agent-based models and simulations to five key
open questions in cancer prevention research. The five research questions we review as
case studies include: 1) What normally prevents somatic evolution from generating
cancer? 2) Why do benign growths often progress to malignant cancers? 3) What is the
chronological sequence of molecular events in cancer progression? 4) Are there reliable
molecular biomarkers for cancer?; and 5) Will evolved drug resistance stymie efforts at
long-term cancer chemoprevention?
We conclude that molecular analysis can be usefully augmented by using agentbased
models to generate plausible and productive hypotheses for empirical testing. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Mountains: Geology, Topography and Environmental Concerns
02.A Short History of the Georgian Church
03.Private Investigations: Suspicion of Financial Crime by White-Collar Criminals
04.Cellular and Molecular Mechanisms of Honey Wound Healing
05.Controversies in Preeclampsia
06.Bioengineering Nursing: New Horizons of Nursing Research
07.Innovation and Global Competition: The Case of Korea
08.Network-Based Continuing Medical Education: Social Media and Professional Development
09.Fractional Calculus in Analysis, Dynamics and Optimal Control
10.The Infinite History of NOW: A Timeless Background for Contemporary Physics
11.Borderline Personality Disorder: Understanding the Unconscious Function of Deliberate Self Harm and Managing the Transference Relationship
12.Energy and Environment Nowadays

Nova Science Publishers
© Copyright 2004 - 2014

Agent-Based Models in Cancer Prevention Research (pp. 105-116)