Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Mathematics and Statistics » Advances in Computational Modeling Research: Theory, Developments and Applications Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
The People of Vietnam: Their Voices and Lived Experiences
$73.80
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Agent-Based Models in Cancer Prevention Research (pp. 105-116)
Tell A Friend
 
Tell someone you know about this product.
Agent-Based Models in Cancer Prevention Research (pp. 105-116) $0.00
Authors:  (John W. Pepper, Nadarajen A. Vydelingum, Barbara K. Dunn, Richard M. Fagerstrom, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA)
Abstract:
Agent-based models have proven very useful for studying complex dynamic
processes. As biomedical researchers have turned their attention to the most complex
diseases, they have made increasing use of agent-based models in various areas,
including cancer biology. Cancer is arguably the ultimate complex biological system. It
has recently become clear that much of its complexity arises through Darwinian
evolution, driven by uncontrolled natural selection among rapidly mutating somatic cells.
Here we review the application of agent-based models and simulations to five key
open questions in cancer prevention research. The five research questions we review as
case studies include: 1) What normally prevents somatic evolution from generating
cancer? 2) Why do benign growths often progress to malignant cancers? 3) What is the
chronological sequence of molecular events in cancer progression? 4) Are there reliable
molecular biomarkers for cancer?; and 5) Will evolved drug resistance stymie efforts at
long-term cancer chemoprevention?
We conclude that molecular analysis can be usefully augmented by using agentbased
models to generate plausible and productive hypotheses for empirical testing. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Global Political Economy after the Crisis: Theoretical Perspectives and Country Experiences
02.Palliative Care: Perspectives, Practices and Impact on Quality of Life. A Global View, Volume 1
03.Trace Metals: Evolution, Environmental and Ecological Significance
04.Informal Learning: Perspectives, Challenges and Opportunities
05.Dissolved Organic Matter (DOM): Properties, Applications and Behavior
06.Green Polymeric Materials: Advances and Sustainable Development
07.Readings in the 20th Century Genocide of the Syriac Orthodox Church of Antioch (Sayfo)
08.Human Collaboration in Homeland Security (DVD Included)
09.Health and Freedom in the Balance: Exploring the Tensions among Public Health, Individual Liberty, and Governmental Authority
10.Innovations in Dialysis Vascular Access Surgery
11.Major Depressive Disorder: Risk Factors, Characteristics and Treatment Options
12.Inulin: Chemical Properties, Uses and Health Benefits

Nova Science Publishers
© Copyright 2004 - 2017

Agent-Based Models in Cancer Prevention Research (pp. 105-116)