Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Genomics » Comparative Genomics in Neglected Human Parasites Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Solution Chemistry: Advances in Research and Applications
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Comparative Genomics of Polyamines Pathway in Amitochondriate Excavata Trichomonas (pp. 115-134)
Tell A Friend
Tell someone you know about this product.
Comparative Genomics of Polyamines Pathway in Amitochondriate Excavata Trichomonas (pp. 115-134) $100.00
Authors:  (María Elizbeth Alvarez Sánchez, Laura Itzel Quintas Granados, César López Camarillo and Bertha Isabel Carvajal Gamez, Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), México City, Mexico, and others)
The recently introduced “Excavata taxa” is classified by its morphological and some
molecular characteristics and this taxa includes at least ten distinct groups such as
Jakobids, Malawimonas, Retortamonads, Trimastix (e.g. Trichomonas), Carpediemonas,
Diplomonads (e.g. Giardia), Heterolobosea, Oxymonads, Parabasalids and Euglenozoa
(e.g. Trypanosoma). Protozoan pathogens classified into the Excavata group can cause
disease and death in millions of humans, primarily in tropical and subtropical regions of
developing countries. These pathogens are dependent of polyamines for their growth,
survival, and virulence properties. Polyamines are polycationic compounds present in all
biological materials and have been implicated in a wide variety of biological reactions,
including synthesis of DNA, RNA, and proteins. Polyamines biosynthetic enzymes are
promising targets for drug development. The ornithine decarboxylase (ODC) inhibitors,
DL-α-difluoromethylornithine (DFMO) and 1-4- diamino- 2- butanone (DAB), are about
to become a first-line drug against human parasitosis such as trichomonosis, giardiasis,
and trypanosomiasis. Enzyme involved in putrescine and spermidine synthesis and
utilization, such as arginase, ornithine decarboxylase (odc), S-adenosylmethionine
decarboxylase (adometdc), spermidine synthase, have been described in Trichomonas
vaginalis and Trypanosoma, while they have been understudied in G. lamblia. The
completion of T. vaginalis, and T. brucei genome and the Giardia genomic information
combined with advances in understanding of polyamines pathway can contribute to the
knowledge of virulence properties and modern drug discovery. In this review, we
emphasize the relevance of these enzymes as drug targets. 

Available Options:
This Item Is Currently Unavailable.
Special Focus Titles
01.Chaliapin and the Jews: The Question of Chaliapin's Purported Antisemitism
02.The Humanities: Past, Present and Future
03.The Poles: Myths and Reality
04.Child-Rearing: Practices, Attitudes and Cultural Differences
05."A Home Away from Home": A Community of International and South African University Students
06.Palliative Care: Oncology Experience from Hong Kong
07.The Enigma of Autism: Genius, Disorder or Just Different?
08.The Collector Mentality: Modernization of the Hunter-Gatherer
09.Face Processing: Systems, Disorders and Cultural Differences
10.Occurrences, Structure, Biosynthesis, and Health Benefits Based on Their Evidences of Medicinal Phytochemicals in Vegetables and Fruits. Volume 8
11.Crystal Growth: Concepts, Mechanisms and Applications
12.The Economic, Social and Political Impact of Mining on Akyem Abuakwa from the Pre-Colonial Era up to 1943

Nova Science Publishers
© Copyright 2004 - 2017

Comparative Genomics of Polyamines Pathway in Amitochondriate Excavata <i>Trichomonas</i> (pp. 115-134)