Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Genomics » Comparative Genomics in Neglected Human Parasites Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
The Life and Times of the World's Most Famous Mathematicians
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Comparative Genomics of Leishmania Parasites (pp. 59-80)
Tell A Friend
Tell someone you know about this product.
Comparative Genomics of Leishmania Parasites (pp. 59-80) $100.00
Authors:  (Norma E. Padilla-Mejía, Claudia M. Gómez-Hurtado, Inti I. Sánchez-Santamaría, Luis E. Florencio-Martínez, Rebeca G. Manning-Cela and Santiago Martínez-Calvillo, Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Mexico, and others)
The parasites of the genus Leishmania are trypanosomatid protozoa that produce a
spectrum of diseases ranging from mild skin or mucosal lesions to fatal visceral
leishmaniasis. The genome sequences of five different species of Leishmania have been
reported to date: L. major, L. infantum, L. braziliensis, L. mexicana and L. donovani.
Analyses of the sequences revealed that the genomes of these parasites are organized into
large directional gene clusters, i.e. tens-to-hundreds of protein-coding genes arranged
sequentially on the same strand of DNA. A remarkable conservation of gene order
(synteny) was observed in the genomes of the different Leishmania species. Interestingly,
an unexpectedly small number of species-specific genes was identified. However, the
analyses showed gene and chromosome copy number differences between species,
indicating that increased gene copy number may cause changes in gene expression that
might influence disease tropism. Contrary to what occurs in other eukaryotes,
transcription in Leishmania and other trypanosomatids is polycistronic, and mature
messenger RNAs (mRNAs) are generated from primary transcripts by trans-splicing and
polyadenylation. Little is known about either the DNA sequences or the proteins that are
involved in transcription initiation in Leishmania. Bioinformatic analyses of the genome
databases of these parasites led to the identification of a small number of proteins
involved in gene expression. However, functional studies have revealed that
trypanosomatids have more general transcription factors than originally estimated.
Analysis of the Leishmania databases showed the presence of a relatively low number of
transfer RNA (tRNA) genes, which are organized into clusters of two to 10 genes that
may contain other Pol III-transcribed genes. Also, with the exception of L. braziliensis,
the Leishmania genome does not contain active retrotransposons. Interestingly, L.
braziliensis possesses components of an RNA-mediated interference pathway, which is
not present in other Leishmania species. 

Available Options:
This Item Is Currently Unavailable.
Special Focus Titles
01.Laryngeal Cancer: Risk Factors, Symptoms and Treatment
02.Breast Surgery: Indications and Techniques
03.Cursed? Biologic and Cultural Aspects of the Menstrual Cycle and Menstruation
04.The Uses of Cocoa and Cupuaçu Byproducts in Industry, Health, and Gastronomy
05.Agriculture, Food, and Food Security: Some Contemporary Global Issues
06.Fungicides: Perspectives, Resistance Management and Risk Assessment
07.Current Developments in Alexithymia - A Cognitive and Affective Deficit
08.Political Concerns and Literary Topoi in French Grand Opera
09.Abdul Aziz Said: The Mualim, The Inspiration
10.Teachers and Teaching: Global Practices, Challenges, and Prospects
11.A Comprehensive Investigation on Executive-Employee Pay Gap of Chinese Enterprises: Antecedents and Consequences
12.American Alligators: Habitats, Behaviors, and Threats

Nova Science Publishers
© Copyright 2004 - 2018

Comparative Genomics of <i>Leishmania</i> Parasites (pp. 59-80)