Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Genomics » Comparative Genomics in Neglected Human Parasites Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Cultural Heritage: Perspectives, Challenges and Future Directions
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Trypanosoma cruzi Genome: Organization, Dynamics, Function and Promise (pp. 19-38)
Tell A Friend
Tell someone you know about this product.
Trypanosoma cruzi Genome: Organization, Dynamics, Function and Promise (pp. 19-38) $100.00
Authors:  (C. Lugo-Caballero, D. Sánchez-Cruz, L.A. Hernández-Osorio, G. Noris-Saravia, M. Rubio-Ortíz, C. Marquez-Dueñas, S. Martínez-Calvillo and R. Manning-Cela, Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del IPN, D.F., Mexico, and others)
The complete genome sequence of Trypanosoma cruzi, the causative agent of
American trypanosomiasis, was published seven years ago. The selected strain, CL
Brener, is a natural hybrid of the T. cruzi II and T. cruzi III lineages. The sequence
analysis revealed that this parasite contains a diploid genome of between 106.4 and 110.7
Mb that is organized into 41 chromosome pairs and 22,570 predicted protein-coding
genes, of which 12,570 represent allelic pairs. Similar to other trypanosomatids, T. cruzi
is characterized by its unique mechanisms of gene expression, such as constitutive
polycistronic transcription and trans-splicing. The parasite genome is organized into
large polycistronic clusters of unrelated genes that are arranged sequentially on the same
DNA strand, which emphasizes the importance of posttranscriptional regulation. T. cruzi
contains a large number of repetitive sequences (≥ 50% of the genome) and includes
large gene families of surface proteins (e.g., TS, mucins, gp63s and MASP),
retrotransposons and subtelomeric repeats. Few promoter sequences have been identified,
and general transcription factors are almost unrepresented. Therefore, little is known
concerning transcription initiation and regulation. The parasite lacks classical RNA
polymerase II promoter sequences. However, it has been shown that transcription
initiation and termination regions are epigenetically marked by histone variants or
modified histones, similarly to other eukaryotes. The chromatin exhibits differential
condensation through the parasite life-cycle stages, and despite the presence of
nucleosomes, chromatin never folds into 30-nm fibers. In this chapter, we intend to detail
the general knowledge of the T. cruzi genome and discuss the most recent discoveries
regarding the regulation of its genome expression and the impact that these findings have
on parasite biology and disease pathogenesis. 

Available Options:
This Item Is Currently Unavailable.
Special Focus Titles
01.Global Political Economy after the Crisis: Theoretical Perspectives and Country Experiences
02.Palliative Care: Perspectives, Practices and Impact on Quality of Life. A Global View, Volume 1
03.Trace Metals: Evolution, Environmental and Ecological Significance
04.Informal Learning: Perspectives, Challenges and Opportunities
05.Dissolved Organic Matter (DOM): Properties, Applications and Behavior
06.Green Polymeric Materials: Advances and Sustainable Development
07.Readings in the 20th Century Genocide of the Syriac Orthodox Church of Antioch (Sayfo)
08.Human Collaboration in Homeland Security (DVD Included)
09.Health and Freedom in the Balance: Exploring the Tensions among Public Health, Individual Liberty, and Governmental Authority
10.Innovations in Dialysis Vascular Access Surgery
11.Major Depressive Disorder: Risk Factors, Characteristics and Treatment Options
12.Inulin: Chemical Properties, Uses and Health Benefits

Nova Science Publishers
© Copyright 2004 - 2017

<i>Trypanosoma cruzi</i> Genome: Organization, Dynamics, Function and Promise (pp. 19-38)