Protein Families in Plasmodium Parasites: A Network Perspective (pp. 1-18)
Authors: (Timothy G. Lilburn, Yufeng Wang, Hong Cai and Jianying Gu, Department of Bacteriology, American Type Culture Collection (ATCC), Manassas, VA, USA, and others)
Abstract: Malaria is one of the most severe global infectious diseases, responsible for over one
million deaths yearly. Protein families play important roles in the life cycle of malaria
parasites Plasmodium, ranging from regulation of gene expression, signal transduction,
cell cycle regulation, transport and trafficking, to pathogenesis/virulence. Members of
these protein families constitute attractive therapeutic targets. In this chapter, we provide
a network overview of malarial protein families, with a special emphasis on
transcriptional regulators and transporters. An improved understanding of the cellular
networks associated with these protein families will uncover system dynamics, protocols,
and the design principles of the Plasmodium parasite, leading to the identification of
novel drug or vaccine targets.
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