Detection/Adsorption of Chemical and Biological Molecules Based on Quartz Crystal Microbalance (QCM) as Sensor (pp. 213-228)
Authors: (M.A. Shenashen, K.K. Shenashen, Department of Optical Science and Technology, Faculty of Engineering, University of Tokushima, Tokushima, Japan, and others)
Abstract: The piezoelectric QCM is an ultrasensitive weighing device around nano-grams,
consisting of a thin disk of single crystal quartz, with metal electrodes deposited on each
side of the disk. The QCM is a simple, cost effective, high-resolution mass sensing
technique, based upon the piezoelectric effect. QCM technique has recognized as a
standard tool that able to provide both qualitative and quantitative information about their
target materials. The high sensitivity and the real-time monitoring of mass changes on the
sensor crystal make QCM a very attractive technique for a large range of applications.
QCM immunosensors have the ability to work directly measure antibody–antigen binding
at the surface of the transducer as label-free, in the same time its surface can be
functionalized with organic and inorganic materials to improve its sensitive and selective
efficiency toward several targets especially biomolecules. QCM sensor suggested being
successfully for early stage clinical diagnosis.